U.K. イギリス Vol.35(G7コーンウォールサミット)

All the below links and tweets are in English.

G7関連情報を含む投稿 及び 日本関連ツイート を取り急ぎ以下貼っておきます。
G7以外の内容も含む 138 及び 140~143 については、内容事項一部抜粋及びマスメディア名等もご参考まで挙げておきます。

World Vol.145 (G7 Summit 2021 in Cornwall)
World Vol.144 (G7 Summit 2021 in Cornwall)
cf. U.K. イギリス Vol.27(England イングランド Vol.9 – South West サウスウェスト地方)

World Vol.143 (U.S., etc.)
G7 … nytimes washingtonpost WSJ chicagotribune nationalpost RTEnews
World Vol.142
G7 PortsmouthNH … Guardian DWNews France24 VancouverSun smh RNZ
World Vol.141 (U.S., etc.)
TikTok-WeChat … ChronicleHerald
World Vol.140 (U.S., etc.)
JanetYellen-GlobalMinimumBusinessTax InteractiveBrokers WisconsinDells … BelferCenter
World Vol.138 (G7, etc.)
G7-finance/foreign/trade-ministers … KOB4

内容例(各回ツイートもご覧ください)
以下、順に、
145:@G7 @BorisJohnson,@POTUS
143:@washingtonpost @nationalpost
142:@euronews @dwnews @guardian @France24_en
141:@MarketWatch2枚 @FBAdvocateNews,@USDA @TheAtlantic,@MichaelSchuman
140:@PluribusPub @business @nytimes,@dealbook @SteveForbesCEO
138:@NASA_Johnson @ABC @krqe
World145 #BuildBackBetter communique-vision-agreement @G7
World145 Biden-Johnson-new-Atlantic-Charter @BorisJohnson,@POTUS
World143 rising-prices @washingtonpost
World143 stock-prices-disconnected-from-fundamentals @nationalpost
World142 eWaste @euronews
World142 US-inflation @dwnews
World142 covid-world @guardian
World142 Uighur @France24_en
World141 gold-futures @MarketWatch
World141 oil-prices @MarketWatch
World141 highest-wildfire-risk @FBAdvocateNews,#DroughtMonitor,@USDA
World141 why-America-afraid-of-TikTok @TheAtlantic
World140 Liberalism-Worth-Saving @PluribusPub
World140 Higher-Interest-Rates @business
World140 historic-global-tax-agreement @nytimes,@dealbook
World140 tax-collectors @SteveForbesCEO
World138 JFK-60years @NASA_Johnson
World138 diamonds-grown-in-labs @ABC
World138 NuclearMuseum @krqe

日本関連ツイート


https://twitter.com/KAS_Japan/status/1404385317059182602
https://twitter.com/Taiwan_in_NL/status/1404036114747478016


https://twitter.com/epaphotos/status/1403040441470177284


https://twitter.com/unclepete_100/status/1404190082005815296

#Coronavirus #コロナウイルス Vol.28

All the below tweets are in English.
標記につき取り急ぎ以下貼っておきます。


https://twitter.com/katyjon/status/1399694623015161860
https://twitter.com/MissManc/status/1399833131469971458


mixing-increases-side-effects @soutikBBC


https://twitter.com/DrEricDing/status/1398631148927004675


https://twitter.com/trtworld/status/1398967555692314626

https://twitter.com/BiIndia/status/1400520157181612036
https://twitter.com/BiIndia/status/1399734985586659332


Pfizer-Covid-jab-produces-less-antibodies-against-Delta-variant @htTweets,@TheLancet


https://twitter.com/FISI_UK/status/1400025769573761024

Recent articles about Japan 日本関連英文記事 Vol.20

標記につき取り急ぎ以下貼っておきます。


https://twitter.com/yasushi_m_Japon/status/1389916976672296960


https://twitter.com/michaeltanchum/status/1395054508728897544


https://twitter.com/BiIndia/status/1399365051975360516


https://twitter.com/wef/status/1389278583172993035
https://twitter.com/mandanggg/status/1388020156123672576

 https://twitter.com/leemakiyama/status/1389098745892114433


https://twitter.com/BISouthAfrica/status/1398006204962648067


https://twitter.com/CBC/status/1382765403550679046


https://twitter.com/AFPphoto/status/1386334182335520775

U.K. イギリス Vol.34

All the below links are in English.

今年のG7サミット主催国(議長国)であるイギリスの最近の動向につき、取り急ぎ以下貼っておきます。

UK Vol.185 (2021 election results, etc.) 選挙結果 等
UK Vol.184 (English local elections, etc.) イングランド統一地方選挙(イギリス下院補欠選挙やロンドン市長選挙を含む)等
UK Vol.183 (Scottish Parliamentary and Welsh Senedd elections) スコットランド議会選挙及びウェールズ議会選挙

UK Vol.181 フィリップ殿下葬儀
UK Vol.180 フィリップ殿下葬儀
UK Vol.178 フィリップ殿下死去
UK Vol.177 フィリップ殿下死去

UK Vol.182 北アイルランド100周年、北アイルランドに関するBrexit議定書 等
UK Vol.179 (incl public policy)
UK Vol.176

内容例(各回ツイートもご覧ください)
以下、順に、
182:@guardian @davidtorrance,@commonslibrary
179:@IISS_org,@purisamir1,@GregDAustin
UK property-sales-16yr-high @guardian
UK NorthernIreland NI-border @davidtorrance,@commonslibrary
UK179 WhitsunReef @IISS_org,@purisamir1,@GregDAustin

#Coronavirus #コロナウイルス Vol.26(financial relief, etc. 財政的支援 等)

JFYI: Here are the English links about financial relief, etc., which were seen on the Internet yesterday.
昨日、ネット上で見かけた標記関連各国状況につき、あくまでご参考まで取り急ぎ以下貼っておきます。

POLICY RESPONSES TO COVID-19: Policy Tracker – Browse by Country (Last updated on 04/06/2021) | @IMFNews

The fiscal response to the economic fallout from the coronavirus (Last updated on 24/11/2020) | Julia Anderson, Enrico Bergamini, Sybrand Brekelmans, Alienor Cameron, Zsolt Darvas, Marta Dominguez Jimenez, Klaas Lenaerts, Catarina Midoes @bruegel

Understanding the impact of government aid to firms in the COVID-19 pandemic (28/06/2020) | Morten Bennedsen, Birthe Larsen, Ian Schmutte, Daniela Scur @VoxEU

Comparing U.S., Japanese, and German Fiscal Responses to Covid-19 (10/28/2020) | @MPGoodman88, Dylan Gerstel @CSIS
@CSIS Comparing U.S., Japanese, and German Fiscal Responses to Covid-19

 

 

 

 

 

Coronavirus: How Are Countries Responding to the Economic Crisis? (Last updated on 05/04/2020) | Jonathan Masters @CFR_org
@CFR_org Coronavirus - How Are Countries Responding to the Economic Crisis - interactive

 

 

 

 

 

COVID-19 pandemic: Financial stability implications and policy measures taken (PDF; 15/04/2020) | @FinStbBoard
Coronavirus26 @FinStbBoard COVID-19 pandemic - Financial stability implications and policy measures taken

 

 

 

 

The initial fiscal policy responses of euro area countries to the COVID-19 crisis (ECB Economic Bulletin 01/2021) | Stephan Haroutunian, Steffen Osterloh, Kamila Slawinska @ecb
Coronavirus26 @ecb The initial fiscal policy responses of euro area countries to the COVID-19 crisis

 

 

 

 

 

Kurzarbeit: Germany’s Short-Time Work Benefit (06/11/2020) | @IMFNews
Coronavirus26 @IMFNews Kurzarbeit- Germany’s Short-Time Work Benefit

 

 

 

Short-time work schemes and their effects on wages and disposable income (04/2020) | @ecb
@ecb Short-time work schemes and their effects on wages & disposable income

 

 

 

 

 

A just and sustainable economic response to coronavirus, explained (03/25/2020) | @drvolts @voxdotcom
@voxdotcom A just and sustainable economic response to coronavirus, explained

 

 

 

 

Overview of Canada’s COVID-19 Economic Response Plan | @FinanceCanada
Coronavirus26 @FinanceCanada Overview of Canada’s COVID-19 Economic Response Plan

 

 

 

 

 

Coronavirus: stimulus policies in other countries after the first shutdown (Updated on 02/24/2021) | Grant Dalton, Thomas Pope @instituteforgov

Coronavirus – check what benefits you can get | @CitizensAdvice

Coronavirus (COVID-19) and Benefits | @nidirect

How effective were stimulus checks in the US? (08/17/2020) | AINE DORIS @chicagoboothrev

Covid-19 Economic Relief | @USTreasury

Coronavirus resources | @BenefitsGOV

COVID-19 and the US economy: FAQ on the economic impact & policy response (03/23/2020) | Jay Shambaugh @BrookingsEcon

Short-Time Compensation Programs As A COVID-19 Response And Recovery Strategy (06/25/2020) | @NatlGovsAssoc

Coronavirus Resources | @USDOL

Economic Response to the Coronavirus – Supporting the Flow of Credit (10/15/2020) | @Treasury_AU

COVID-19 benefits and services | Canada.ca

Building effective short-time work schemes for the COVID-19 crisis | Giulia Giupponi & Camille Landais @voxeu

Short-time working compensation | work.swiss

Lay-offs and short-time working | GOV.UK

Coronavirus (COVID-19): SME policy responses (15/06/2020) | @OECD

The Economic Impact of Coronavirus in the U.S. and Possible Economic Policy Responses (03/03/2020) | @amprog

Covid Performance Index | @LowyInstitute

World 世界情勢等 Vol.14 / U.S.A. アメリカ Vol.169

All the below links are in English.

取り急ぎ以下(内容事項一部抜粋ご参考まで)貼っておきます。

World Vol.119
semiconductor history WashingtonDC EG,BR,PH,IR,KR,CN,RU NZ,AU,CA,UK
World Vol.118 (U.S., etc.)
ArabSpring Arctic AI-hackers MassShootings commercial-RealEstate Uyghur-Xinjiang immigration IR,AF,MM,TW,NK,PK,CU,CN,RU
World Vol.117 (U.S., etc.)
Ramadan-Mecca RetailSales Amazon AdamToledo-Chicago BlackSea T.rex Amazon,AL IN,WA RU,CN,CA,TR,UG,HU,TW,IR,CU,ET,TD
World Vol.116 (U.S., etc.)
HousePrices-HousingMarket books Moderna-Nexus Coinbase-IPO ThomasMiller-UKP&I Canterbury AstraZeneca bee FL,NM CN,IR,AF,IN,NZ,AU
World Vol.115 (U.S., etc.)
Belt&Road EU BlackRock rare-BloodClots MexicanBorder DerekChauvin-GeorgeFloyd Prince-Welcome2America PrincePhilip COVID-VaccineCard MinnesotaTwins MT,WV,CA,OH,MN NK,CN,MM,IR
World Vol.114 (U.S.)
Easter CherryBlossom Arctic LaborMarket hackers COVID19-passports PublicSafety-BodyCameras FL,DC,MI,AZ,WI IC,NZ,AM,AF
World Vol.113 (U.S., etc.)
stocks water vaccines,vaccination Say’sLaw NorthernIreland 1969GuamDoctrine LBJ GermanNorwegianSubmarine Quad CentralAmerica PineappleWar Pfizer NASA Microsoft Amazon KeystoneXL HokkaidoRamen&Sushi AK,TX,TN,AZ,MT SA,AF,IN,IR,NK,CN,FR
World Vol.112 (AFP, abcnews, 12News, etc.)
TropicalDeforestation SouthChinaSea Pfizer HIPAA AZ CU,CO,BR,ZA,EG,CF,AU,PH,MY,MM,CY,UK,IC,RU,HU,IT,FR,BE,DE AU:HousePrices Coronavirus ZombieMines Qld NSW

内容例(各回ツイートもご覧ください)
以下、順に、
112:@LMdiplo、@AZDHS
113:@AspenStrategy,@ForeignAffairs
114:@cnni
116:@TheEconomist
117:@AFP,@Yahoo
118:@nytimes
119:@DeccanHerald,@nytimes、@mattskala,JonStokes,@doxanotes

World112 Patents-Prevents-Vaccines-For-All @LMdiplo
Arizona9-World112 masks @AZDHS
World113 America-Should-Vaccinate-The-World @AspenStrategy,@ForeignAffairs
World114 #Easter,#EasterSunday @cnni
World116 house-price @TheEconomist
World117 BlackSea @AFP,@Yahoo
World118 commercial-office-buildings @nytimes
World119 GlobalChipShortage @DeccanHerald,@nytimes
World119 China-invasion @mattskala,JonStokes,@doxanotes

Recent articles about Japan 日本関連英文記事 Vol.17(incl Asia and U.S.)

This is next.

続きです。


https://twitter.com/ccahart/status/1378545791011332097


https://twitter.com/Frances_Coppola/status/374142867801133056


https://twitter.com/sparrowhawk28/status/1377538288739815424

4/15以降追加  “Ever Given” re-floated in Suez Canal (13/04/2021) | @UKPandI


https://twitter.com/Nihonpolitics/status/1375426752521109508

World 世界情勢等 Vol.13 / U.S.A. アメリカ Vol.165

All the below links are in English.

取り急ぎ以下(内容事項一部抜粋ご参考まで)貼っておきます。

World Vol.111 (Biden’s First Press Conference)
World Vol.110 (U.S. President Biden’s First Press Conference)
World Vol.108 (sanctions, human rights)
World Vol.107 (sanctions, human rights)
World Vol.106 (Alaska meeting)
World Vol.99 (G7 online summit meeting)

World Vol.109 (U.S., etc.)
TransAtlantic-NATO NorthernIreland BankOfEngland Houthi Russia China Japan-earthquake CanadianPacificRailway-KansasCity,MO VaccinePassports space-cheese HappinessReport PowerOutages TX
World Vol.105 (U.S. diplomacy, etc.)
Russia China Belarus ROK EU-Turkey Arctic NATO UK India Medicago(Qc,CA) HateCrimes-racism NordStream2 WesternBalkans UnitedAirlines Zoo-bonobos-orangutans Oxford-AstraZeneca CARES StPatricksDay hail-Ozarks MO
World Vol.104 (U.S., etc.)
Novavax Venezuela Paraguay UAE OPEC CA,AU,NZ AR
World Vol.103 (U.S., etc.)
EVs cheese AU-SuperState Iraq Italy vaccine stimulus OH
World Vol.102 (U.S., etc.)
CA-China Myanmar KazuoIshiguro Sarkozy meat-packing-plant COVID-passport AU NZ-earthquake KS,NE

内容例(各回ツイートもご覧ください)
順に、
109:@CarnegieEndow,@Judy_Dempsey
105:@kostigen,@DefenseOne、@CSISEnergy,@CSIS、@ACScowcroft
104:@SPGlobalPlatts、@CFR_org、@ArkBusiness、@a_shiryaevskaya,@BloombergNRG
103:@energyathaas、@wef、@GoldmanSchool,@NatalieHolmes3,@CAPolicyLab,@UCBerkeley、@WSBresearch,@BrookingsInst,@pewtrusts,@squinton_states
102:@CEPS_thinktank、@amandajanepaul,@Mihai_Chihaia,@epc_eu、@lklades,@EconPsyPol,@ucdgearyinst,@Kate_Laffan,@UCD_Research、@CAGlobalAffairs,@BenHautecouv,@FRS_org

World109 NI @CarnegieEndow,@Judy_Dempsey

World105 metals-supply-chain @kostigen @DefenseOne
World105 Nakano US-EU-Jp rare-earth @CSISEnergy @CSIS
Oklahoma10 OKState chickpeas @healthline @okstatefapc

World104 atlas-metals-SupplyChain @SPGlobalPlatts
World104 Venezuela @CFR_org,CRS
World104-Arkansas Bentonville-developer @ArkBusiness
World104 Asia-thirst-NaturalGas @a_shiryaevskaya,@BloombergNRG

World103 first-fix-NaturalGas-market @energyathaas
World103 forest-biodiversity @wef
World103 movingOutOf-SF-not-Calif @GoldmanSchool,@NatalieHolmes3,@CAPolicyLab,@UCBerkeley
World103 not-boost-economic-activity @WSBresearch,@BrookingsInst,@pewtrusts,@squinton_states

World102 Balkan-EasternEuropean-Comparisons @CEPS_thinktank
World102 US-Iran-JCPOA @amandajanepaul,@Mihai_Chihaia,@epc_eu
World102 economic-preferences-predict-proenvironmental-behaviour-altruism @lklades,@EconPsyPol,@ucdgearyinst,@Kate_Laffan,@UCD_Research
World102 Europe-continent-strategic-autonomy @CAGlobalAffairs,@BenHautecouv,@FRS_org

World 世界情勢等 Vol.10(Biden Administration バイデン米政権) / U.S.A. アメリカ Vol.131

All the below links and tweets are in English.

標記につき取り急ぎ以下貼っておきます。

就任式 inauguration
World Vol.79 (U.S. Presidential Inauguration Day – Ireland, United Kingdom)
World Vol.80 (U.S. Presidential Inauguration Day – Canada)
World Vol.81 (U.S. Presidential Inauguration Day – New Zealand, Europe, etc.)
World Vol.82 (U.S. Presidential Inauguration Day – Australia)
World Vol.83 (U.S. Presidential Inauguration, Biden Administration, etc.)
政策課題 policy issues
World Vol.84 (Biden Administration, etc. – U.S. think tanks)
World Vol.85 (Biden Administration, etc. – U.S. think tanks)
World Vol.86 (Biden Administration, etc. – U.S. think tanks)
World Vol.87 (Biden Administration – U.S. think tanks, etc. @ universities)

新大統領及び日本に関連するツイート


https://twitter.com/DerekJGrossman/status/1352646250722586627


https://twitter.com/NextGenTaiwan/status/1352218957134983172

Science and Technology 科学技術 Vol.19 / #Coronavirus #コロナウイルス Vol.22(pharmaceutical products 医薬品 Vol.8:drugs 治療薬)

All the below links and excerpts are in English.

Sarilumab (Kevzara®) に係るリンクと当方作成の抜粋を取り急ぎ以下のとおり貼っておきます。
cf.
Science and Technology 科学技術 Vol.14 / #Coronavirus #コロナウイルス Vol.15(pharmaceutical products 医薬品 Vol.6:drugs 治療薬) Tocilizumab
Science and Technology 科学技術 Vol.15 / #Coronavirus #コロナウイルス Vol.16(pharmaceutical products 医薬品 Vol.7:drugs 治療薬)

Clinicians encouraged to consider tocilizumab or sarilumab in treatment of hospitalised COVID-19 patients (07/01/2021) | @PJOnline_News,@robinson_julia
… The new advice, which is due to be published on 8 January 2020, follows results released from the Randomised, Embedded, Multi-factorial, Adaptive Platform Trial for Community-Acquired pneumonia (REMAP-CAP), which suggested that tocilizumab and sarilumab, which are both IL-6 receptor antagonists, led to a 24% reduced risk of mortality, when administered to patients within 24 hours of entering intensive care. …
At the time of full analysis, 353 patients had been assigned to tocilizumab, 48 to sarilumab and 402 to standard care. The majority of patients were also treated with corticosteroids, such as dexamethasone, and were receiving respiratory support.
The trial data yielded an odds ratio of 1.64 for a better outcome with tocilizumab, and 1.76 for sarilumab, compared to no immune modulation, with a high degree of statistical certainty.
…Anthony Gordon…
Gino Martini, chief scientist at the Royal Pharmaceutical Society…
Tocilizumab and sarilumab have already been added to the government’s export restriction list, which bans companies from buying medicines meant for UK patients and selling them on for a higher price in another country. This will protect supply for UK patients by enforcing regulatory action on those who flout the restrictions.

Roche’s Actemra, Regeneron’s Kevzara win U.K.’s favor in COVID-19 after study shows 24% drop in death risk (01/08/2021) | @FiercePharma,@arleneweintraub
The question of whether seriously ill COVID-19 patients can benefit from anti-inflammatories like Roche’s Actemra and Sanofi and Regeneron’s Kevzara has dogged practitioners in the United States thanks to conflicting clinical trial results.
The United Kingdom, on the other hand, has reached a definitive answer on the two drugs, both of which are IL-6 inhibitors: They significantly reduce the risk of death in COVID-19 patients needing intensive care, and they should be used to ease the pressure hospitals are now facing as the coronavirus pandemic continues to intensify, the country’s National Institute for Health Research (NIHR) said Thursday.
The recommendation came after data from an NIHR-sponsored study showed that Actemra and Kevzara can cut hospital stays for COVID-19 patients admitted to intensive care by 10 days and can lower the risk of death by 24% in patients who receive either drug within a day of admission. That finding prompted the U.K. government to recommend to the National Health Service (NHS) that IL-6 inhibitors be rolled out for the treatment of COVID-19. …

UK Covid patients to receive new drugs tocilizumab and sarilumab that reduce death risk by 24% (w Video; 01/08/2021) | @EveningStandard,@HattieBrewis
… NHS patients admitted to the country’s intensive care units will be able to receive tocilizumab and sarilumab, which have also been found to reduce the time coronavirus sufferers need to spend in hospital by up to 10 days. …
It comes after results from the Government-funded REMAP-CAP clinical trial showed that both drugs reduced the risk of mortality by 8.5 per cent when administered to patients within a day of entering intensive care alongside a corticosteroid, such as dexamethasone.
Professor Anthony Gordon, chair in anaesthesia and critical care at Imperial College London and a consultant in intensive care medicine at Imperial College Healthcare NHS Trust…
Hospital mortality was 27.3 per cent among patients receiving tocilizumab or sarilumab, compared with 35.8 per cent of patients in the control group who did not receive the drugs, the researchers said.
Treatment with tocilizumab or sarilumab is thought to cost somewhere between £750 and £1,000 and is administered intravenously either as a one or two dose regime.
Professor Gordon added: “For every 12 patients in intensive care you treat with these drugs, based on the evidence we saw, you would expect to save one life.” …
Tocilizumab and sarilumab have been added to the Government’s export restriction list, the Department of Health and Social Care (DHSC) said.
This will protect supply for UK patients by enforcing regulatory action on those who flout the restrictions, it added.
Commenting on the findings, Peter Horby, professor of Emerging Infectious Diseases, the University of Oxford’s Centre for Tropical Medicine and Global Health…
“Importantly, the findings of a benefit are in addition to corticosteroids, which were taken by 93 per cent of the participants.
“This means we now have two drugs, which combined have a greater effect.”

KEVZARA HELPS INHIBIT THE EFFECTS OF CHRONICALLY ELEVATED IL-6: KEVZARA targets and binds with high affinity to soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R), thereby inhibiting IL-6 signaling | @sanofi & @Regeneron
Sarilumab-Kevzara1 mechanism

UK approves anti-inflammatory drugs to treat sickest covid-19 patients after strong results in clinical trial (01/08/2021) | @washingtonpost,@Carolynyjohnson,@bbguari
…Jonathan Parr…
David E. Leaf, a Harvard Medical School assistant professor and Brigham and Women’s Hospital physician, said the data were game-changing: “For ICU patients, I think it is a slam dunk that they should be given tocilizumab if it can be given early on.”…
“We’re currently live in 290 sites around the world, and so there was no way to quietly whisper to 290 sites: ‘Stop randomizing to control in the immune modulation arm, but don’t tell anyone,’ ” said Derek Angus, chair of critical care medicine at the University of Pittsburgh Medical Center and one of the investigators of the trial. …
The list price of the dose of Kevzara used in the trial is about $3,600. The maximum dose used in the trial of Actemra currently carries a list price of $4,600, but the dose varied by patients’ body weight and could be given either once or twice. Bob Purcell, a spokesman for Genentech, a member of the Roche Group, said that the drug was not approved for use in covid-19 and the pricing might differ if it were approved to treat the illness. …
About 36 percent of patients died in the hospital who received standard care, while 28 percent died on tocilizumab and 22 percent died when given sarilumab. Patients treated with the drugs spent about a week less in the ICU, on average. …

UK Approves Arthritis Drugs for Critically Ill COVID-19 Patients (01/11/2021) | @TheScientistLLC,@AsherGJones
… The study, which has not yet been peer-reviewed, evaluated around 800 patients in intensive care with severe COVID-19. Around half received the standard of care while 353 received tocilizumab and 48 received sarilumab. The researchers found that 35.8 percent of those given standard care died, compared with 28 percent who received tocilizumab and 22.2 percent who were given sarilumab. …
The immunosuppressive drugs tocilizumab and sarilumab, which are primarily used to treat arthritis, block signaling of the cytokine IL-6, a key regulator of immune dysregulation and inflammation in severe COVID-19 cases. …
…Krutika Kuppalli, an infectious disease physician at the Medical University of South Carolina… @nytimes
…Jonathan Parr, an infectious diseases physician at the University of North Carolina at Chapel Hill… @washingtonpost

Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis (04/03/2021) | National Center for Biotechnology Information, U.S. National Library of Medicine
Sarilumab-Kevzara4 NIH-RA-developmentSarilumab-Kevzara3 NIH-RApatients-strategySarilumab-Kevzara5 NIH-SideEffects

Kevzara (Sarilumab injection, for subcutaneous use): side effects (05/18/2018) | @RxList
Kevzara (sarilumab) injection is an interleukin-6 (IL-6) receptor antagonist indicated for treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs). Common side effects of Kevzara include:
・low white blood cell count (neutropenia),
・increased ALT,
・injection site redness,
・upper respiratory infections,
・nasal congestion,
・runny nose,
・sore throat,
・urinary tract infections, and
・low platelet counts (thrombocytopenia). …

Sarilumab (Kevzara®) Drug Information Sheet | @jhrheumatology
Sarilumab-Kevzara2 JH-SideEffects

Kevzara Side Effects (09/13/2020) | @Drugscom
Side effects requiring immediate medical attention
… Check with your doctor immediately if any of the following side effects occur while taking sarilumab:
More common
・Bloody, black, or tarry stools
・chills
・cough
・fever
・lower back or side pain
・painful or difficult urination
・pale skin
・sore throat
・ulcers, sores, or white spots in the mouth
・unusual bleeding or bruising
・unusual tiredness or weakness
Less common
・bladder pain
・bloody or cloudy urine
・body ache or pain
・difficulty breathing
・ear congestion
・frequent urge to urinate
・headache
・loss of voice
・nasal congestion
・painful cold sores or blisters on the lips
・runny nose
・sneezing
Rare
・difficulty swallowing
・dizziness
・fast heartbeat
・heartburn
・hives, itching, skin rash
・indigestion
・nausea
・puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
・severe stomach pain, cramping, or burning
・tightness in the chest
・vomiting of material that looks like coffee grounds, severe and continuing
Side effects not requiring immediate medical attention
More common
・bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
For Healthcare Professionals
Dermatologic; Hematologic; Hypersensitivity; Immunologic; Local; Metabolic; Genitourinary; Hepatic; Respiratory; General; Gastrointestinal

Kevzara (Sarilumab), a New IL-6 Receptor Antagonist, Approved for Active Rheumatoid Arthritis (03/2018) | American Health & Drug Benefits @TheLynxGroup
Mechanism of Action
Sarilumab is a human recombinant monoclonal antibody that binds to IL-6 receptors that inhibit IL-6?mediated signaling. The IL-6 cytokine plays a role in the body’s inflammatory process and response. The production of IL-6 by synovial and endothelial cells can lead to local production of IL-6 in the joints affected by RA and other inflammatory processes. Elevated levels of IL-6 have been correlated with disease activity and joint damage in patients with RA.
Dosing and Administration
The recommended dosage of sarilu-mab is 200 mg once every 2 weeks, administered as a subcutaneous injection; it is available as a 150-mg/1.14-mL or 200-mg/1.14-mL solution in a single-dose, prefilled syringe, and can be used as monotherapy or in combination with methotrexate or other conventional DMARDs. …
Adverse Reactions
The most common (incidence ≧3%) adverse reactions associated with saril-umab therapy are neutropenia (7%), increased alanine aminotransferase levels (5%), injection-site erythema (5%), upper respiratory infections (4%), and urinary tract infections (3%).
Drug Interactions
Cytokines and cytokine modulators can influence the activity of specific cytochrome (CY) P450 enzymes (including CYP3A4) and thus may alter the metabolism of drugs that are substrates of these enzymes. Use caution when sarilumab is co-administered with CYP3A4 substrate drugs for which decreased effectiveness is undesirable (eg, oral contraceptives, statins).
Use in Specific Populations
Nursing women may need to discontinue sarilumab or discontinue nursing.
No differences in safety or efficacy of sarilumab were seen between older (aged ≧65 years) and younger patients.
Warnings and Precautions
The prescribing information for saril-umab includes a boxed warning stating that sarilumab is associated with an increased risk for serious and potentially fatal infections, including bacterial, viral, invasive fungal, and other opportunistic infections. Patients should be monitored closely for infection while receiving sarilumab.
Sarilumab has been associated with reduced ANC, including neutropenia; a reduction in platelet counts; transaminase elevations; and lipid abnormalities.
The risk for gastrointestinal perforation may be increased when sarilumab is used concomitantly with NSAIDs or with corticosteroids.
Treatment with immunosuppressant drugs, including sarilumab, may increase the risk for malignancies.
Sarilumab should be discontinued immediately if anaphylaxis or a hypersensitivity reaction occurs.
Sarilumab should not be used with live vaccines.
* Kevzara (sarilumab) injection [prescribing information]. Tarrytown, NY: Regeneron Pharmaceuticals; Bridgewater, NJ: sanofi-aventis U.S.; May 2017.

Repurposed Drugs to Fight SARS-CoV-2, Tocilizumab and Sarilumab – Part 4 (04/15/2021) | @_Monocl
Tocilizumab and sarilumab reduce COVID-19 patient mortality by 8.5 percent, data shows (07/01/2021) | @PharmaReview
Kevzara (sarilumab) | @mnt
Sarilumab (Subcutaneous Route) | @MayoClinic
Efficacy and safety of sarilumab in patients with active rheumatoid arthritis (01/11/2018) | National Center for Biotechnology Information, U.S. National Library of Medicine
Sarilumab | @sciencedirect