Recent articles about Japan 日本関連英文記事 Vol.5

All the below tweets are in English.

Recent articles about Japan 日本関連英文記事 Vol.4

All the below tweets are in English.

Science and Technology 科学技術 Vol.19 / #Coronavirus #コロナウイルス Vol.22(pharmaceutical products 医薬品 Vol.8:drugs 治療薬)

All the below links and excerpts are in English.

Sarilumab (Kevzara®) に係るリンクと当方作成の抜粋を取り急ぎ以下のとおり貼っておきます。
cf.
Science and Technology 科学技術 Vol.14 / #Coronavirus #コロナウイルス Vol.15(pharmaceutical products 医薬品 Vol.6:drugs 治療薬) Tocilizumab
Science and Technology 科学技術 Vol.15 / #Coronavirus #コロナウイルス Vol.16(pharmaceutical products 医薬品 Vol.7:drugs 治療薬)

Clinicians encouraged to consider tocilizumab or sarilumab in treatment of hospitalised COVID-19 patients (07/01/2021) | @PJOnline_News,@robinson_julia
… The new advice, which is due to be published on 8 January 2020, follows results released from the Randomised, Embedded, Multi-factorial, Adaptive Platform Trial for Community-Acquired pneumonia (REMAP-CAP), which suggested that tocilizumab and sarilumab, which are both IL-6 receptor antagonists, led to a 24% reduced risk of mortality, when administered to patients within 24 hours of entering intensive care. …
At the time of full analysis, 353 patients had been assigned to tocilizumab, 48 to sarilumab and 402 to standard care. The majority of patients were also treated with corticosteroids, such as dexamethasone, and were receiving respiratory support.
The trial data yielded an odds ratio of 1.64 for a better outcome with tocilizumab, and 1.76 for sarilumab, compared to no immune modulation, with a high degree of statistical certainty.
…Anthony Gordon…
Gino Martini, chief scientist at the Royal Pharmaceutical Society…
Tocilizumab and sarilumab have already been added to the government’s export restriction list, which bans companies from buying medicines meant for UK patients and selling them on for a higher price in another country. This will protect supply for UK patients by enforcing regulatory action on those who flout the restrictions.

Roche’s Actemra, Regeneron’s Kevzara win U.K.’s favor in COVID-19 after study shows 24% drop in death risk (01/08/2021) | @FiercePharma,@arleneweintraub
The question of whether seriously ill COVID-19 patients can benefit from anti-inflammatories like Roche’s Actemra and Sanofi and Regeneron’s Kevzara has dogged practitioners in the United States thanks to conflicting clinical trial results.
The United Kingdom, on the other hand, has reached a definitive answer on the two drugs, both of which are IL-6 inhibitors: They significantly reduce the risk of death in COVID-19 patients needing intensive care, and they should be used to ease the pressure hospitals are now facing as the coronavirus pandemic continues to intensify, the country’s National Institute for Health Research (NIHR) said Thursday.
The recommendation came after data from an NIHR-sponsored study showed that Actemra and Kevzara can cut hospital stays for COVID-19 patients admitted to intensive care by 10 days and can lower the risk of death by 24% in patients who receive either drug within a day of admission. That finding prompted the U.K. government to recommend to the National Health Service (NHS) that IL-6 inhibitors be rolled out for the treatment of COVID-19. …

UK Covid patients to receive new drugs tocilizumab and sarilumab that reduce death risk by 24% (w Video; 01/08/2021) | @EveningStandard,@HattieBrewis
… NHS patients admitted to the country’s intensive care units will be able to receive tocilizumab and sarilumab, which have also been found to reduce the time coronavirus sufferers need to spend in hospital by up to 10 days. …
It comes after results from the Government-funded REMAP-CAP clinical trial showed that both drugs reduced the risk of mortality by 8.5 per cent when administered to patients within a day of entering intensive care alongside a corticosteroid, such as dexamethasone.
Professor Anthony Gordon, chair in anaesthesia and critical care at Imperial College London and a consultant in intensive care medicine at Imperial College Healthcare NHS Trust…
Hospital mortality was 27.3 per cent among patients receiving tocilizumab or sarilumab, compared with 35.8 per cent of patients in the control group who did not receive the drugs, the researchers said.
Treatment with tocilizumab or sarilumab is thought to cost somewhere between £750 and £1,000 and is administered intravenously either as a one or two dose regime.
Professor Gordon added: “For every 12 patients in intensive care you treat with these drugs, based on the evidence we saw, you would expect to save one life.” …
Tocilizumab and sarilumab have been added to the Government’s export restriction list, the Department of Health and Social Care (DHSC) said.
This will protect supply for UK patients by enforcing regulatory action on those who flout the restrictions, it added.
Commenting on the findings, Peter Horby, professor of Emerging Infectious Diseases, the University of Oxford’s Centre for Tropical Medicine and Global Health…
“Importantly, the findings of a benefit are in addition to corticosteroids, which were taken by 93 per cent of the participants.
“This means we now have two drugs, which combined have a greater effect.”

KEVZARA HELPS INHIBIT THE EFFECTS OF CHRONICALLY ELEVATED IL-6: KEVZARA targets and binds with high affinity to soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R), thereby inhibiting IL-6 signaling | @sanofi & @Regeneron
Sarilumab-Kevzara1 mechanism

UK approves anti-inflammatory drugs to treat sickest covid-19 patients after strong results in clinical trial (01/08/2021) | @washingtonpost,@Carolynyjohnson,@bbguari
…Jonathan Parr…
David E. Leaf, a Harvard Medical School assistant professor and Brigham and Women’s Hospital physician, said the data were game-changing: “For ICU patients, I think it is a slam dunk that they should be given tocilizumab if it can be given early on.”…
“We’re currently live in 290 sites around the world, and so there was no way to quietly whisper to 290 sites: ‘Stop randomizing to control in the immune modulation arm, but don’t tell anyone,’ ” said Derek Angus, chair of critical care medicine at the University of Pittsburgh Medical Center and one of the investigators of the trial. …
The list price of the dose of Kevzara used in the trial is about $3,600. The maximum dose used in the trial of Actemra currently carries a list price of $4,600, but the dose varied by patients’ body weight and could be given either once or twice. Bob Purcell, a spokesman for Genentech, a member of the Roche Group, said that the drug was not approved for use in covid-19 and the pricing might differ if it were approved to treat the illness. …
About 36 percent of patients died in the hospital who received standard care, while 28 percent died on tocilizumab and 22 percent died when given sarilumab. Patients treated with the drugs spent about a week less in the ICU, on average. …

UK Approves Arthritis Drugs for Critically Ill COVID-19 Patients (01/11/2021) | @TheScientistLLC,@AsherGJones
… The study, which has not yet been peer-reviewed, evaluated around 800 patients in intensive care with severe COVID-19. Around half received the standard of care while 353 received tocilizumab and 48 received sarilumab. The researchers found that 35.8 percent of those given standard care died, compared with 28 percent who received tocilizumab and 22.2 percent who were given sarilumab. …
The immunosuppressive drugs tocilizumab and sarilumab, which are primarily used to treat arthritis, block signaling of the cytokine IL-6, a key regulator of immune dysregulation and inflammation in severe COVID-19 cases. …
…Krutika Kuppalli, an infectious disease physician at the Medical University of South Carolina… @nytimes
…Jonathan Parr, an infectious diseases physician at the University of North Carolina at Chapel Hill… @washingtonpost

Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis (04/03/2021) | National Center for Biotechnology Information, U.S. National Library of Medicine
Sarilumab-Kevzara4 NIH-RA-developmentSarilumab-Kevzara3 NIH-RApatients-strategySarilumab-Kevzara5 NIH-SideEffects

Kevzara (Sarilumab injection, for subcutaneous use): side effects (05/18/2018) | @RxList
Kevzara (sarilumab) injection is an interleukin-6 (IL-6) receptor antagonist indicated for treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs). Common side effects of Kevzara include:
・low white blood cell count (neutropenia),
・increased ALT,
・injection site redness,
・upper respiratory infections,
・nasal congestion,
・runny nose,
・sore throat,
・urinary tract infections, and
・low platelet counts (thrombocytopenia). …

Sarilumab (Kevzara®) Drug Information Sheet | @jhrheumatology
Sarilumab-Kevzara2 JH-SideEffects

Kevzara Side Effects (09/13/2020) | @Drugscom
Side effects requiring immediate medical attention
… Check with your doctor immediately if any of the following side effects occur while taking sarilumab:
More common
・Bloody, black, or tarry stools
・chills
・cough
・fever
・lower back or side pain
・painful or difficult urination
・pale skin
・sore throat
・ulcers, sores, or white spots in the mouth
・unusual bleeding or bruising
・unusual tiredness or weakness
Less common
・bladder pain
・bloody or cloudy urine
・body ache or pain
・difficulty breathing
・ear congestion
・frequent urge to urinate
・headache
・loss of voice
・nasal congestion
・painful cold sores or blisters on the lips
・runny nose
・sneezing
Rare
・difficulty swallowing
・dizziness
・fast heartbeat
・heartburn
・hives, itching, skin rash
・indigestion
・nausea
・puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
・severe stomach pain, cramping, or burning
・tightness in the chest
・vomiting of material that looks like coffee grounds, severe and continuing
Side effects not requiring immediate medical attention
More common
・bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
For Healthcare Professionals
Dermatologic; Hematologic; Hypersensitivity; Immunologic; Local; Metabolic; Genitourinary; Hepatic; Respiratory; General; Gastrointestinal

Kevzara (Sarilumab), a New IL-6 Receptor Antagonist, Approved for Active Rheumatoid Arthritis (03/2018) | American Health & Drug Benefits @TheLynxGroup
Mechanism of Action
Sarilumab is a human recombinant monoclonal antibody that binds to IL-6 receptors that inhibit IL-6?mediated signaling. The IL-6 cytokine plays a role in the body’s inflammatory process and response. The production of IL-6 by synovial and endothelial cells can lead to local production of IL-6 in the joints affected by RA and other inflammatory processes. Elevated levels of IL-6 have been correlated with disease activity and joint damage in patients with RA.
Dosing and Administration
The recommended dosage of sarilu-mab is 200 mg once every 2 weeks, administered as a subcutaneous injection; it is available as a 150-mg/1.14-mL or 200-mg/1.14-mL solution in a single-dose, prefilled syringe, and can be used as monotherapy or in combination with methotrexate or other conventional DMARDs. …
Adverse Reactions
The most common (incidence ≧3%) adverse reactions associated with saril-umab therapy are neutropenia (7%), increased alanine aminotransferase levels (5%), injection-site erythema (5%), upper respiratory infections (4%), and urinary tract infections (3%).
Drug Interactions
Cytokines and cytokine modulators can influence the activity of specific cytochrome (CY) P450 enzymes (including CYP3A4) and thus may alter the metabolism of drugs that are substrates of these enzymes. Use caution when sarilumab is co-administered with CYP3A4 substrate drugs for which decreased effectiveness is undesirable (eg, oral contraceptives, statins).
Use in Specific Populations
Nursing women may need to discontinue sarilumab or discontinue nursing.
No differences in safety or efficacy of sarilumab were seen between older (aged ≧65 years) and younger patients.
Warnings and Precautions
The prescribing information for saril-umab includes a boxed warning stating that sarilumab is associated with an increased risk for serious and potentially fatal infections, including bacterial, viral, invasive fungal, and other opportunistic infections. Patients should be monitored closely for infection while receiving sarilumab.
Sarilumab has been associated with reduced ANC, including neutropenia; a reduction in platelet counts; transaminase elevations; and lipid abnormalities.
The risk for gastrointestinal perforation may be increased when sarilumab is used concomitantly with NSAIDs or with corticosteroids.
Treatment with immunosuppressant drugs, including sarilumab, may increase the risk for malignancies.
Sarilumab should be discontinued immediately if anaphylaxis or a hypersensitivity reaction occurs.
Sarilumab should not be used with live vaccines.
* Kevzara (sarilumab) injection [prescribing information]. Tarrytown, NY: Regeneron Pharmaceuticals; Bridgewater, NJ: sanofi-aventis U.S.; May 2017.

Repurposed Drugs to Fight SARS-CoV-2, Tocilizumab and Sarilumab – Part 4 (04/15/2021) | @_Monocl
Tocilizumab and sarilumab reduce COVID-19 patient mortality by 8.5 percent, data shows (07/01/2021) | @PharmaReview
Kevzara (sarilumab) | @mnt
Sarilumab (Subcutaneous Route) | @MayoClinic
Efficacy and safety of sarilumab in patients with active rheumatoid arthritis (01/11/2018) | National Center for Biotechnology Information, U.S. National Library of Medicine
Sarilumab | @sciencedirect

World 世界情勢等 Vol.9

All the below links are in English.

取り急ぎ以下(内容事項一部抜粋ご参考まで)貼っておきます。

World Vol.69 (economics/economy) HymanMinsky,MinskyMoment Ponzi InstabilityHypothesis HerbertStein DirkBezemer ModernMonetaryTheory,MMT PostKeynesian MarcLavoie JanHatzius TiagoMata JonathanSchlefer
World Vol.68 (economics/economy, etc.) MiltonFriedman MartinWolf StephenKinsella GennaroZezza UBI EricBeinhocker bloomberg
World Vol.67 (Modern Monetary Theory #MMT, etc.) HymanMinsky,MinskyMoment ScottSumner WilliamMitchell RandallWray MartinWatts WarrenMosler PaulMcCulley ScottFullwiler WynneGodley StephanieKelton
World Vol.66 ClimateAction EconomicMeltdown IanGoldin broadband,digitization WorldEconomy Gazprom Shopify,Cargojet Russia vaccine CountryMusic MostAnticipatedBooks BestFantasyBooks MustReadBooks fireworks BarronPublicAffairs-list
World Vol.65 (Coronavirus, etc.) Oxford-AstraZeneca vaccine,vaccines UK Beethoven EuropeanUnion megabanks China,WELT TradeAndCooperationAgreement ClothMasks,PPE OysterShells,PPE TN,CA
World Vol.64 (U.K., U.S., etc.) BorisJohnson UrsulaVonDerLeyen TonyBlair GavinNewsom relief CARESact CA,PA
World Vol.63 (U.S., etc.) cybersecurity ConfederateFlags UK Canada Cuomo Amazon BarackObama,FavotiteMusic OutlawOceanP OH,NY
World Vol.62 (U.S., Australia, Canada, France, Spain, Sweden, etc.) EmmanuelMacron KingOfSweden CanadianComics barley,China,WTO,LoseLose Palestinian NY,NC,VA,SC
World Vol.61 (U.S., etc.) BehavioralScience cybersecurity FreeWorld AI military FederalDebt ElectoralCollege UrbanRuralDivide China vaccine ImmigrationSystem HospitalMonopolies monolith RentersRights Floodlines-podcast
World Vol.60 (U.S., finance, etc.) ForeignPolicy FinancialPolicy,MonetaryPolicy Oracle LegalChallenge,SCOTUS AG Cuomo Olympia,WA 1949polio UW NorthernLights GA,TX,WI,MI

Canada カナダ Vol.9

Almost all the below tweets/links are in English.

最近の日加公館等ツイートと、2019年総選挙・少数単独政権発足からコロナ禍までの投稿をまとめて、取り急ぎ以下貼っておきます。

Canada Vol.32 (public policy)
Canada Vol.31 (Québec – cities, province)
Canada Vol.30 (Ontario – cities, regions, province)
Canada Vol.29 (think tanks, universities)
Canada Vol.28 (universities)
Canada Vol.27 (newspapers, TV, etc. – public policy & federal election 2019)
Canada Vol.26 (universities & think tanks – public policy & election 2019)

https://twitter.com/invest_canada/status/1336402554075418625


https://twitter.com/CanEmbJapan/status/1341631979897446401


https://twitter.com/CanEmbJapan/status/1339838219983212544
https://twitter.com/CanEmbJapan/status/1339401151440171008
https://twitter.com/CanEmbJapan/status/1338728869373861888
https://twitter.com/CanEmbJapan/status/1337203855176634370
https://twitter.com/CanEmbJapan/status/1336903405860687872
https://twitter.com/CanEmbJapan/status/1336896823848542209


https://twitter.com/CanEmbJapan/status/1333589775866077187


https://twitter.com/CanEmbJapan/status/1331053883708366848
https://twitter.com/CanEmbJapan/status/1329562775904014337
https://twitter.com/CanEmbJapan/status/1328502235786063872
https://twitter.com/CanEmbJapan/status/1328127958305935360
https://twitter.com/CanEmbJapan/status/1327136803346927616


https://twitter.com/CanEmbJapan/status/1323530612561584131


https://twitter.com/IanBurneyJapan/status/1339787674333396992


https://twitter.com/IanBurneyJapan/status/1324633782432006145


https://twitter.com/TXTChartData/status/1343544707884998656


https://twitter.com/AmbKawamura/status/1335988387304632322


https://twitter.com/JapaninCanada/status/1339616573238210560

Cyber Security etc. サイバーセキュリティ等 Vol.6

All the below tweets are in English.

取り急ぎ標記につき以下貼っておきます。

https://twitter.com/cybercentre_ca/status/1343587737060913154

https://twitter.com/Cybersec_EU/status/1339153321584680960


https://twitter.com/IASME1/status/1336325096885997571


https://twitter.com/Cyberchallenge/status/1323578481230422017


https://twitter.com/GCHQ/status/1343215312762761218
https://twitter.com/CHCyberPolicy/status/1324665041296281602


https://twitter.com/USCERT_gov/status/1339618633383899136


https://twitter.com/CorelliumHQ/status/1343192287015276550


https://twitter.com/DeptofDefense/status/1336005285517803520

U.K. イギリス Vol.33(Scotland スコットランド)


https://twitter.com/BroughtonRugby/status/1263743531895709701
https://twitter.com/ChampionsCup/status/1159864487731703809


https://twitter.com/EdinburghRugby/status/1182567679577808896


https://twitter.com/MofaJp_Sports/status/1320603041100304385


https://twitter.com/jordanmurray_/status/1342591872062074880
https://twitter.com/citizenM/status/962657556291379201
https://twitter.com/lovesanimation/status/1312430896541241345


https://twitter.com/UofGlasgow/status/1176161801911906306


https://twitter.com/TheCastleHunter/status/1311241476496592897


https://twitter.com/natlibscot/status/1139494949416820736


https://twitter.com/BritishCycling/status/1189209274632855552

U.K. イギリス Vol.32(Brexit, Coronavirus, etc. ブレグジット、コロナウイルス など)

All the below tweets/links are in English.

UK Vol.175 (Coronavirus, Brexit, 2019, etc.)
UK Vol.172
UK Vol.171
UK Vol.173 (pharmaceutical corporations: Seqirus) / Australia Vol.30
UK Vol.174 (quality & safety solutions corporations: Intertek)
cf. World Vol.64 (U.K., U.S., etc.)

ツイッター検索で日英両国関連につき出て来たもの(Brexit関連は多くありません)を取り急ぎ以下貼っておきます。多数見つかりましたので Vol.33 に続きます。
https://twitter.com/tradegovuk/status/1319492163823128576


https://twitter.com/trussliz/status/1334472682184859648


https://twitter.com/visitjapanuk/status/1341024192079294468
https://twitter.com/visitjapanuk/status/1342087457341321217


https://twitter.com/MSCintheUK/status/1341764770366681088


https://twitter.com/BBCSport/status/1218937411155021824


https://twitter.com/bopinion/status/1330499821661261824
https://twitter.com/LoveIsNeededNow/status/1338845481154310144


Vol.33 に続きます。 Please go on to Vol.33. It was a good surprise that I was able to easily find many tweets regarding Japan-Scotland.

France フランス Vol.7

France Vol.23 (Brexit, European Union, Emmanuel Macron, Coronavirus, etc.)
France Vol.22 (incl Giscard d’Estaing)
France Vol.20 (Valery Giscard d’Estaing)
France Vol.19 (think tanks, lockdown, etc.)
France Vol.18 (think tanks, etc.)
France Vol.14 (think tanks, banks)
France Vol.21 (eyewear corporations: Bollé Safety)

ツイッター検索で日仏両国関連につき出て来たもの を取り急ぎ以下貼っておきます。


https://twitter.com/FRS_org/status/1179345763211583488


https://twitter.com/FFJ_EHESS/status/1327184489567694849


https://twitter.com/CNRSinJapan/status/1328635561196756993


https://twitter.com/lejaponparis/status/1335841618054811648


https://twitter.com/ambafrancejp_jp/status/1313770951432007681


https://twitter.com/ambafrancejp/status/1337779370379759618
https://twitter.com/ambafrancejp/status/1336858567605952514


https://twitter.com/ambafrancejp/status/1327183826938892288


https://twitter.com/ffgymnastique/status/1335967652867674112
https://twitter.com/ffgymnastique/status/1342477701475684353
https://twitter.com/FFAthletisme/status/1341075561037377537
https://twitter.com/AmbJaponFR/status/1342772139623993346
https://twitter.com/AmbJaponFR/status/1342170093577510912
https://twitter.com/AmbJaponFR/status/1342107765230215169
https://twitter.com/AmbJaponFR/status/1341770363483672578
https://twitter.com/AmbJaponFR/status/1341428288242257920
https://twitter.com/AmbJaponFR/status/1341322587977129984
https://twitter.com/AmbJaponFR/status/1340960202300899329


https://twitter.com/AmbJaponFR/status/1339955427992363009


https://twitter.com/AmbJaponFR/status/1338061101804773377
https://twitter.com/AmbJaponFR/status/982168024307286016


https://twitter.com/sciencespo/status/697764998064566272


https://twitter.com/sciencespo/status/1084419799839580160
https://twitter.com/sciencespo/status/1122455924894052352
https://twitter.com/sciencespo/status/1217009209163894785


https://twitter.com/Splashpodcast/status/1222934500604284931


https://twitter.com/VNiquet/status/1255043786683621379
https://twitter.com/VNiquet/status/1299269550467317760

Germany ドイツ Vol.6

Germany Vol.27 (Angela Merkel, lockdown, etc.)
Germany Vol.24 (think tanks, lockdown, etc.)
Germany Vol.26 (medical & safety technology corporations: Dräger)
Germany Vol.25 (pharmaceutical corporations: CureVac)

ツイッター検索で日独両国関連につき出て来たもの を取り急ぎ以下貼っておきます。
https://twitter.com/kas_tokyo/status/1340858228976992257
https://twitter.com/kas_tokyo/status/1339096675114106881
https://twitter.com/kas_tokyo/status/1334305771547283456


https://twitter.com/kas_tokyo/status/1328869758310121473


https://twitter.com/kas_tokyo/status/1327100599758831616
 https://twitter.com/kas_tokyo/status/1323216314744279040
 https://twitter.com/HistoryStrategy/status/1341169675091251201
https://twitter.com/PhilippePoet/status/1135807101358317568
https://twitter.com/PhilippePoet/status/1061841308896047104
https://twitter.com/DWIH_Tokyo/status/1075307245657829376
https://twitter.com/potato_japan/status/1340727422120046593
https://twitter.com/MiguelBergerAA/status/1339889158693785601
https://twitter.com/MiguelBergerAA/status/1334502814698131457
https://twitter.com/MiguelBergerAA/status/1308771970331410432


https://twitter.com/GermanyDiplo/status/1197870095860731904


https://twitter.com/GermanyDiplo/status/1232660701023481856
https://twitter.com/GermanyDiplo/status/1311724278228955136


https://twitter.com/GermanyDiplo/status/1021713879540346881
https://twitter.com/GERonEconomy/status/1244744086847979527
https://twitter.com/GERonEconomy/status/1040618182757756928


https://twitter.com/UN_Disarmament/status/1334540857119281158


https://twitter.com/EUJapanCentre/status/1197470726393126917


https://twitter.com/architectourGD/status/1340234166139564034


https://twitter.com/4BerlinTokyo/status/1337347549339013122


https://twitter.com/GermanyinJapan/status/1338978391513583617
https://twitter.com/GermanyinJapan/status/1340499666782146561


https://twitter.com/GermanyinJapan/status/1324919755791167489
https://twitter.com/GermanyinWestjp/status/1339369626514419712


https://twitter.com/GermanyinWestjp/status/1340446822419017737
https://twitter.com/GermanyinWestjp/status/1337948350008545282


https://twitter.com/GTAI_de/status/1192455251523198977


https://twitter.com/BotschaftJapan/status/1139095124049367040


https://twitter.com/SHIKIBU_Automat/status/1340837300385632258


https://twitter.com/RickAnderson/status/1340520730010689536


https://twitter.com/EnkiSort33/status/1334625147463086091
https://twitter.com/FutureLuiss/status/1339480456044146691


 https://twitter.com/Forbes/status/1047958289923940354
 https://twitter.com/qingyulaser/status/1341172398087794689
 https://twitter.com/MaxBoot/status/1014526312600522753