U.S.A. アメリカ Vol.138(New York ニューヨーク州 Vol.6 / U.S. universities and colleges 米国大学:Cornell)

Almost all the below tweets/links are in English.

取り急ぎ以下貼っておきます。

U.S. universities and colleges Vol.7 (Cornell, Dartmouth) / New York Vol.40 / New Hampshire Vol.16
cf.
U.S. universities and colleges Vol.4 (universities)
New York Vol.3
U.S.A. アメリカ Vol.27(Policies & Midterms 各種政策等 Vol.1 -大学ツイート Massachusetts~Pennsylvania)

コーネル大学と日本に関連するツイート


https://twitter.com/CherryArtspace/status/1049733283964170240
https://twitter.com/SewardHouse/status/1011695940024131584


https://twitter.com/SOAlumniNetwork/status/1133391128760332288


https://twitter.com/CornellLRC/status/1329802978107199490


https://twitter.com/CornellMBA/status/1217235009154756608
https://twitter.com/CornellMBA/status/1252628292814942210


https://twitter.com/Judi_Byers/status/1285052144031272962


https://twitter.com/CornellMBA/status/1114694317468266496
https://twitter.com/CornellMBA/status/942907661049303040


https://twitter.com/ItsJennyChen/status/739954563655032832
https://twitter.com/TheTaiwanTimes/status/1322495436297445376


https://twitter.com/BradZarnett/status/1243964567354572800

U.S.A. アメリカ Vol.137(Ohio オハイオ州 Vol.2 / U.S. universities and colleges 米国大学:Ohio State、Case Western Reserve)

All the below links and tweets are in English.

取り急ぎ以下貼っておきます。

U.S. universities and colleges Vol.13 (Case Western Reserve) / Ohio Vol.9
U.S. universities and colleges Vol.14 (Ohio State) / Ohio Vol.10

cf.
Ohio Vol.4 (cities)
U.S.A. アメリカ Vol.30(Policies & Midterms 各種政策等 Vol.4 -大学ツイート Louisiana~Michigan)

オハイオ州立大学やケースウェスタンリザーブ大学と日本に関連するツイート


https://twitter.com/pashulman/status/461163241389817856


https://twitter.com/CBUSRegion/status/1161632066905288705
https://twitter.com/UNCCD/status/1085807003652435968


https://twitter.com/garthdahdah/status/1091272915524440064
https://twitter.com/BTNLiveBIG/status/1122966535209984000
https://twitter.com/BTNLiveBIG/status/1116726988226662401
https://twitter.com/JapanPrizeAward/status/1111631856951328768


https://twitter.com/JapanPrizeAward/status/1085396119272734720


https://twitter.com/OSUGlobal/status/1125759904940285952
https://twitter.com/OSUGlobal/status/1040608310116974592
https://twitter.com/OSUGlobal/status/1022832814692200448


https://twitter.com/OSUGlobal/status/954443151762214914

U.S.A. アメリカ Vol.136(Illinois イリノイ州 Vol.4 / U.S. universities and colleges 米国大学:The University of Chicago)

All the below links and tweets are in English.

取り急ぎ以下貼っておきます。

U.S. universities and colleges Vol.5 (UChicago, Stanford, Harvard, Yale)
cf.
Illinois Vol.8 (cities, counties)
Free papers, reports, et al. Vol.32
Free papers, reports, et al. Vol.30
Free papers, reports, et al. Vol.22 (Professor Richard H. Thaler – 2017 Nobel Economics Prize laureate – Vol.2)
Free papers, reports, et al. Vol.21 (Professor Richard H. Thaler – 2017 Nobel Economics Prize laureate – Vol.1)
World Vol.15 (U.S. universities)
U.S.A. アメリカ Vol.31(Policies & Midterms 各種政策等 Vol.5 -大学ツイート Indiana・Illinois)

シカゴ大学及び日本に関連するツイート


https://twitter.com/AsiaMattersPod/status/1314600229665034240


https://twitter.com/jesswade/status/1027843343693369345

U.S.A. アメリカ Vol.135(incl Biden’s first phone call with Suga 日米首脳電話会談等)

Almost all the below tweets are in English.

標記につき取り急ぎ以下貼っておきます。


https://twitter.com/Quicktake/status/1352648758799052813


https://twitter.com/Noahpinion/status/1352332544209948672

World 世界情勢等 Vol.11 / U.S.A. アメリカ Vol.134

All the below links are in English.

取り急ぎ以下(内容事項一部抜粋ご参考まで)貼っておきます。

World Vol.88 (U.S., Canada, Australia, New Zealand, etc.) SalvatorMundi gaming tourism Kimchi Ca,Au,Nz KeystoneXLpipeline SD
World Vol.78 (U.S., etc.) YellowstoneNationalPark ALDI BigMacIndex Flint CrystalNight Australia MA,WY,UT,MD
World Vol.77 (Reuters, etc.) impeachment vaccines CoucheTard WilliamHill Refinitiv resolution PoliticalContributions PA
World Vol.76 US&Europe-China&Russia EUbudget austerity Mercury-Jupiter-Saturn BloodDonors StimulusPayments crawfish MealDelivery FrozenVegetables KFC Parler Cruz TX,LA
World Vol.75 (U.S. – professors) impeachment 25thAmendment removal
World Vol.74 (U.S., etc.) vaccine Hawley CarryoutCocktails MO,NE
World Vol.73 (U.S. – Georgia runoffs, etc.) / Georgia Vol.8 ChaosAtTheCapitol GA,TN
World Vol.72 (U.S. – Chaos in Washington D.C., etc.) / Washington D.C. Vol.6 insurrection,riot,sedition
World Vol.71 (U.S. – Chaos in Washington D.C.) / Washington D.C. Vol.5 storming,lawlessness,mayhem,rampage
World Vol.70 (U.S. – Chaos in Washington D.C.) / Washington D.C. Vol.4 mob,violence InsurrectionaryMob ViolentAttack CapitolRioters ViolentProtesters NeoNazis UnprecedentedAssault 25thAmendment

Science and Technology 科学技術 Vol.20 / U.S.A. アメリカ Vol.132 (pharmaceutical companies, etc. 製薬会社等)

All the below links are in English.

取り急ぎ以下貼っておきます。

Massachusetts Vol.27 (corporations: ImmunoGen)

Massachusetts Vol.26 (corporations: Ironwood Pharmaceuticals)

Massachusetts Vol.25 (corporations: Sarepta Therapeutics)

Massachusetts Vol.24 (corporations: Alexion Pharmaceuticals)

Massachusetts Vol.23 (corporations: Vertex Pharmaceuticals) / Switzerland Vol.8 (pharmaceutical corporations: CRISPR Therapeutics)

Massachusetts Vol.22 (corporations: Boston Scientific)

Massachusetts Vol.21 (corporations: Thermo Fisher Scientific)

New Jersey Vol.12 (corporations: Amicus Therapeutics)

New Jersey Vol.11 (corporations: PTC Therapeutics)

Pennsylvania Vol.13 (corporations: Inovio Pharmaceuticals)

Pennsylvania Vol.12 (corporations: Mylan)

Delaware Vol.8 (corporations: Incyte)

North Carolina Vol.13 (corporations: LabCorp)

Michigan Vol.11 (corporations: Stryker)

Illinois Vol.13 (corporations: GE Healthcare)

Illinois Vol.12 (corporations: Abbott Laboratories)

California Vol.30 (corporations: Intuitive Surgical)

California Vol.29 (corporations: Nektar Therapeutics)

California Vol.28 (corporations: Halozyme Therapeutics)

California Vol.27 (corporations: Illumina)

Texas Vol.16 (corporations: McKesson Corporation)

アメリカ最大手等10社強については当日本語サイトにおいても既に投稿済ですので、州ごとに適宜お探しください。
cf.
Massachusetts Vol.20 (corporations: Biogen)
Massachusetts Vol.19 (corporations: Moderna)
New York Vol.37 (corporations: Regeneron)
New York Vol.36 (corporations: Bristol Myers Squibb)
New York Vol.35 (corporations: Pfizer)
New Jersey Vol.10 (corporations: Merck (Merck Sharp & Dohme (MSD) outside the U.S. & Canada))
New Jersey Vol.9 (corporations: Johnson & Johnson)
Pennsylvania Vol.11 (corporations: CSL Behring) / Australia Vol.29
Maryland Vol.9 (corporations: Novavax)
Indiana Vol.8 (corporations: Eli Lilly)
Illinois Vol.14 (corporations: Baxter International)
Illinois Vol.11 (corporations: AbbVie)
California Vol.26 (corporations: Gilead Sciences)
California Vol.25 (corporations: Amgen)

#Coronavirus #コロナウイルス Vol.23(vaccines, etc. ワクチン等)

All the below link/tweets are in English.

取り急ぎ以下貼っておきます。

Science and Technology Vol.50 (coronavirus vaccine)  Vaccination SideEffects,AdverseReactions,AllergicReaction,AnaphylaxisReaction,PotentialTriggers,AllergyConcerns …

関連する最近のツイート


https://twitter.com/Daily_Express/status/1352246043845517315


https://twitter.com/wiltscouncil/status/1350844347793747968


https://twitter.com/POLITICOEurope/status/1351213890621886468


https://twitter.com/tamer_hadi/status/1352682427836207104


https://twitter.com/timesofindia/status/1351155661078474756

なお、リンク、ツイート及び記事を当サイトに貼る目的は、当サイトを訪れた方々が色んな情報に触れ満足されることです。弊社としては、煽る等の目的はもちろん常々ありませんし、現実にツイッター上に流れているものをなるべく予断や偏り無く時間の許す限りで一応貼っています。
Please note: the purpose we paste tweets on this website is that the visitors to this site will be satisfied with the visits because they can see various information here. Of course, we always have no intention of agitation, etc. We just paste tweets, which are actually on Twitter, with as little prejudication and bias as possible, as time permits.

World 世界情勢等 Vol.10(Biden Administration バイデン米政権) / U.S.A. アメリカ Vol.131

All the below links and tweets are in English.

標記につき取り急ぎ以下貼っておきます。

就任式 inauguration
World Vol.79 (U.S. Presidential Inauguration Day – Ireland, United Kingdom)
World Vol.80 (U.S. Presidential Inauguration Day – Canada)
World Vol.81 (U.S. Presidential Inauguration Day – New Zealand, Europe, etc.)
World Vol.82 (U.S. Presidential Inauguration Day – Australia)
World Vol.83 (U.S. Presidential Inauguration, Biden Administration, etc.)
政策課題 policy issues
World Vol.84 (Biden Administration, etc. – U.S. think tanks)
World Vol.85 (Biden Administration, etc. – U.S. think tanks)
World Vol.86 (Biden Administration, etc. – U.S. think tanks)
World Vol.87 (Biden Administration – U.S. think tanks, etc. @ universities)

新大統領及び日本に関連するツイート


https://twitter.com/DerekJGrossman/status/1352646250722586627


https://twitter.com/NextGenTaiwan/status/1352218957134983172

Recent articles about Japan 日本関連英文記事 Vol.5

All the below tweets are in English.


https://twitter.com/CCHQPress/status/1319556636562829314


https://twitter.com/ls1228/status/1347390249228333056

Science and Technology 科学技術 Vol.19 / #Coronavirus #コロナウイルス Vol.22(pharmaceutical products 医薬品 Vol.8:drugs 治療薬)

All the below links and excerpts are in English.

Sarilumab (Kevzara®) に係るリンクと当方作成の抜粋を取り急ぎ以下のとおり貼っておきます。
cf.
Science and Technology 科学技術 Vol.14 / #Coronavirus #コロナウイルス Vol.15(pharmaceutical products 医薬品 Vol.6:drugs 治療薬) Tocilizumab
Science and Technology 科学技術 Vol.15 / #Coronavirus #コロナウイルス Vol.16(pharmaceutical products 医薬品 Vol.7:drugs 治療薬)

Clinicians encouraged to consider tocilizumab or sarilumab in treatment of hospitalised COVID-19 patients (07/01/2021) | @PJOnline_News,@robinson_julia
… The new advice, which is due to be published on 8 January 2020, follows results released from the Randomised, Embedded, Multi-factorial, Adaptive Platform Trial for Community-Acquired pneumonia (REMAP-CAP), which suggested that tocilizumab and sarilumab, which are both IL-6 receptor antagonists, led to a 24% reduced risk of mortality, when administered to patients within 24 hours of entering intensive care. …
At the time of full analysis, 353 patients had been assigned to tocilizumab, 48 to sarilumab and 402 to standard care. The majority of patients were also treated with corticosteroids, such as dexamethasone, and were receiving respiratory support.
The trial data yielded an odds ratio of 1.64 for a better outcome with tocilizumab, and 1.76 for sarilumab, compared to no immune modulation, with a high degree of statistical certainty.
…Anthony Gordon…
Gino Martini, chief scientist at the Royal Pharmaceutical Society…
Tocilizumab and sarilumab have already been added to the government’s export restriction list, which bans companies from buying medicines meant for UK patients and selling them on for a higher price in another country. This will protect supply for UK patients by enforcing regulatory action on those who flout the restrictions.

Roche’s Actemra, Regeneron’s Kevzara win U.K.’s favor in COVID-19 after study shows 24% drop in death risk (01/08/2021) | @FiercePharma,@arleneweintraub
The question of whether seriously ill COVID-19 patients can benefit from anti-inflammatories like Roche’s Actemra and Sanofi and Regeneron’s Kevzara has dogged practitioners in the United States thanks to conflicting clinical trial results.
The United Kingdom, on the other hand, has reached a definitive answer on the two drugs, both of which are IL-6 inhibitors: They significantly reduce the risk of death in COVID-19 patients needing intensive care, and they should be used to ease the pressure hospitals are now facing as the coronavirus pandemic continues to intensify, the country’s National Institute for Health Research (NIHR) said Thursday.
The recommendation came after data from an NIHR-sponsored study showed that Actemra and Kevzara can cut hospital stays for COVID-19 patients admitted to intensive care by 10 days and can lower the risk of death by 24% in patients who receive either drug within a day of admission. That finding prompted the U.K. government to recommend to the National Health Service (NHS) that IL-6 inhibitors be rolled out for the treatment of COVID-19. …

UK Covid patients to receive new drugs tocilizumab and sarilumab that reduce death risk by 24% (w Video; 01/08/2021) | @EveningStandard,@HattieBrewis
… NHS patients admitted to the country’s intensive care units will be able to receive tocilizumab and sarilumab, which have also been found to reduce the time coronavirus sufferers need to spend in hospital by up to 10 days. …
It comes after results from the Government-funded REMAP-CAP clinical trial showed that both drugs reduced the risk of mortality by 8.5 per cent when administered to patients within a day of entering intensive care alongside a corticosteroid, such as dexamethasone.
Professor Anthony Gordon, chair in anaesthesia and critical care at Imperial College London and a consultant in intensive care medicine at Imperial College Healthcare NHS Trust…
Hospital mortality was 27.3 per cent among patients receiving tocilizumab or sarilumab, compared with 35.8 per cent of patients in the control group who did not receive the drugs, the researchers said.
Treatment with tocilizumab or sarilumab is thought to cost somewhere between £750 and £1,000 and is administered intravenously either as a one or two dose regime.
Professor Gordon added: “For every 12 patients in intensive care you treat with these drugs, based on the evidence we saw, you would expect to save one life.” …
Tocilizumab and sarilumab have been added to the Government’s export restriction list, the Department of Health and Social Care (DHSC) said.
This will protect supply for UK patients by enforcing regulatory action on those who flout the restrictions, it added.
Commenting on the findings, Peter Horby, professor of Emerging Infectious Diseases, the University of Oxford’s Centre for Tropical Medicine and Global Health…
“Importantly, the findings of a benefit are in addition to corticosteroids, which were taken by 93 per cent of the participants.
“This means we now have two drugs, which combined have a greater effect.”

KEVZARA HELPS INHIBIT THE EFFECTS OF CHRONICALLY ELEVATED IL-6: KEVZARA targets and binds with high affinity to soluble and membrane-bound IL-6 receptors (sIL-6R and mIL-6R), thereby inhibiting IL-6 signaling | @sanofi & @Regeneron
Sarilumab-Kevzara1 mechanism

UK approves anti-inflammatory drugs to treat sickest covid-19 patients after strong results in clinical trial (01/08/2021) | @washingtonpost,@Carolynyjohnson,@bbguari
…Jonathan Parr…
David E. Leaf, a Harvard Medical School assistant professor and Brigham and Women’s Hospital physician, said the data were game-changing: “For ICU patients, I think it is a slam dunk that they should be given tocilizumab if it can be given early on.”…
“We’re currently live in 290 sites around the world, and so there was no way to quietly whisper to 290 sites: ‘Stop randomizing to control in the immune modulation arm, but don’t tell anyone,’ ” said Derek Angus, chair of critical care medicine at the University of Pittsburgh Medical Center and one of the investigators of the trial. …
The list price of the dose of Kevzara used in the trial is about $3,600. The maximum dose used in the trial of Actemra currently carries a list price of $4,600, but the dose varied by patients’ body weight and could be given either once or twice. Bob Purcell, a spokesman for Genentech, a member of the Roche Group, said that the drug was not approved for use in covid-19 and the pricing might differ if it were approved to treat the illness. …
About 36 percent of patients died in the hospital who received standard care, while 28 percent died on tocilizumab and 22 percent died when given sarilumab. Patients treated with the drugs spent about a week less in the ICU, on average. …

UK Approves Arthritis Drugs for Critically Ill COVID-19 Patients (01/11/2021) | @TheScientistLLC,@AsherGJones
… The study, which has not yet been peer-reviewed, evaluated around 800 patients in intensive care with severe COVID-19. Around half received the standard of care while 353 received tocilizumab and 48 received sarilumab. The researchers found that 35.8 percent of those given standard care died, compared with 28 percent who received tocilizumab and 22.2 percent who were given sarilumab. …
The immunosuppressive drugs tocilizumab and sarilumab, which are primarily used to treat arthritis, block signaling of the cytokine IL-6, a key regulator of immune dysregulation and inflammation in severe COVID-19 cases. …
…Krutika Kuppalli, an infectious disease physician at the Medical University of South Carolina… @nytimes
…Jonathan Parr, an infectious diseases physician at the University of North Carolina at Chapel Hill… @washingtonpost

Update on the Pathomechanism, Diagnosis, and Treatment Options for Rheumatoid Arthritis (04/03/2021) | National Center for Biotechnology Information, U.S. National Library of Medicine
Sarilumab-Kevzara4 NIH-RA-developmentSarilumab-Kevzara3 NIH-RApatients-strategySarilumab-Kevzara5 NIH-SideEffects

Kevzara (Sarilumab injection, for subcutaneous use): side effects (05/18/2018) | @RxList
Kevzara (sarilumab) injection is an interleukin-6 (IL-6) receptor antagonist indicated for treatment of adult patients with moderately to severely active rheumatoid arthritis (RA) who have had an inadequate response or intolerance to one or more disease-modifying antirheumatic drugs (DMARDs). Common side effects of Kevzara include:
・low white blood cell count (neutropenia),
・increased ALT,
・injection site redness,
・upper respiratory infections,
・nasal congestion,
・runny nose,
・sore throat,
・urinary tract infections, and
・low platelet counts (thrombocytopenia). …

Sarilumab (Kevzara®) Drug Information Sheet | @jhrheumatology
Sarilumab-Kevzara2 JH-SideEffects

Kevzara Side Effects (09/13/2020) | @Drugscom
Side effects requiring immediate medical attention
… Check with your doctor immediately if any of the following side effects occur while taking sarilumab:
More common
・Bloody, black, or tarry stools
・chills
・cough
・fever
・lower back or side pain
・painful or difficult urination
・pale skin
・sore throat
・ulcers, sores, or white spots in the mouth
・unusual bleeding or bruising
・unusual tiredness or weakness
Less common
・bladder pain
・bloody or cloudy urine
・body ache or pain
・difficulty breathing
・ear congestion
・frequent urge to urinate
・headache
・loss of voice
・nasal congestion
・painful cold sores or blisters on the lips
・runny nose
・sneezing
Rare
・difficulty swallowing
・dizziness
・fast heartbeat
・heartburn
・hives, itching, skin rash
・indigestion
・nausea
・puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
・severe stomach pain, cramping, or burning
・tightness in the chest
・vomiting of material that looks like coffee grounds, severe and continuing
Side effects not requiring immediate medical attention
More common
・bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
For Healthcare Professionals
Dermatologic; Hematologic; Hypersensitivity; Immunologic; Local; Metabolic; Genitourinary; Hepatic; Respiratory; General; Gastrointestinal

Kevzara (Sarilumab), a New IL-6 Receptor Antagonist, Approved for Active Rheumatoid Arthritis (03/2018) | American Health & Drug Benefits @TheLynxGroup
Mechanism of Action
Sarilumab is a human recombinant monoclonal antibody that binds to IL-6 receptors that inhibit IL-6?mediated signaling. The IL-6 cytokine plays a role in the body’s inflammatory process and response. The production of IL-6 by synovial and endothelial cells can lead to local production of IL-6 in the joints affected by RA and other inflammatory processes. Elevated levels of IL-6 have been correlated with disease activity and joint damage in patients with RA.
Dosing and Administration
The recommended dosage of sarilu-mab is 200 mg once every 2 weeks, administered as a subcutaneous injection; it is available as a 150-mg/1.14-mL or 200-mg/1.14-mL solution in a single-dose, prefilled syringe, and can be used as monotherapy or in combination with methotrexate or other conventional DMARDs. …
Adverse Reactions
The most common (incidence ≧3%) adverse reactions associated with saril-umab therapy are neutropenia (7%), increased alanine aminotransferase levels (5%), injection-site erythema (5%), upper respiratory infections (4%), and urinary tract infections (3%).
Drug Interactions
Cytokines and cytokine modulators can influence the activity of specific cytochrome (CY) P450 enzymes (including CYP3A4) and thus may alter the metabolism of drugs that are substrates of these enzymes. Use caution when sarilumab is co-administered with CYP3A4 substrate drugs for which decreased effectiveness is undesirable (eg, oral contraceptives, statins).
Use in Specific Populations
Nursing women may need to discontinue sarilumab or discontinue nursing.
No differences in safety or efficacy of sarilumab were seen between older (aged ≧65 years) and younger patients.
Warnings and Precautions
The prescribing information for saril-umab includes a boxed warning stating that sarilumab is associated with an increased risk for serious and potentially fatal infections, including bacterial, viral, invasive fungal, and other opportunistic infections. Patients should be monitored closely for infection while receiving sarilumab.
Sarilumab has been associated with reduced ANC, including neutropenia; a reduction in platelet counts; transaminase elevations; and lipid abnormalities.
The risk for gastrointestinal perforation may be increased when sarilumab is used concomitantly with NSAIDs or with corticosteroids.
Treatment with immunosuppressant drugs, including sarilumab, may increase the risk for malignancies.
Sarilumab should be discontinued immediately if anaphylaxis or a hypersensitivity reaction occurs.
Sarilumab should not be used with live vaccines.
* Kevzara (sarilumab) injection [prescribing information]. Tarrytown, NY: Regeneron Pharmaceuticals; Bridgewater, NJ: sanofi-aventis U.S.; May 2017.

Repurposed Drugs to Fight SARS-CoV-2, Tocilizumab and Sarilumab – Part 4 (04/15/2021) | @_Monocl
Tocilizumab and sarilumab reduce COVID-19 patient mortality by 8.5 percent, data shows (07/01/2021) | @PharmaReview
Kevzara (sarilumab) | @mnt
Sarilumab (Subcutaneous Route) | @MayoClinic
Efficacy and safety of sarilumab in patients with active rheumatoid arthritis (01/11/2018) | National Center for Biotechnology Information, U.S. National Library of Medicine
Sarilumab | @sciencedirect