タグ: 太平洋

Germany ドイツ Vol.6

Germany Vol.27 (Angela Merkel, lockdown, etc.)
Germany Vol.24 (think tanks, lockdown, etc.)
Germany Vol.26 (medical & safety technology corporations: Dräger)
Germany Vol.25 (pharmaceutical corporations: CureVac)

ツイッター検索で日独両国関連につき出て来たもの を取り急ぎ以下貼っておきます。
https://twitter.com/kas_tokyo/status/1340858228976992257
https://twitter.com/kas_tokyo/status/1339096675114106881
https://twitter.com/kas_tokyo/status/1334305771547283456


https://twitter.com/kas_tokyo/status/1328869758310121473


https://twitter.com/kas_tokyo/status/1327100599758831616
　https://twitter.com/kas_tokyo/status/1323216314744279040
　https://twitter.com/HistoryStrategy/status/1341169675091251201
https://twitter.com/PhilippePoet/status/1135807101358317568
https://twitter.com/PhilippePoet/status/1061841308896047104
https://twitter.com/DWIH_Tokyo/status/1075307245657829376
https://twitter.com/potato_japan/status/1340727422120046593
https://twitter.com/MiguelBergerAA/status/1339889158693785601
https://twitter.com/MiguelBergerAA/status/1334502814698131457
https://twitter.com/MiguelBergerAA/status/1308771970331410432


https://twitter.com/GermanyDiplo/status/1197870095860731904


https://twitter.com/GermanyDiplo/status/1232660701023481856
https://twitter.com/GermanyDiplo/status/1311724278228955136


https://twitter.com/GermanyDiplo/status/1021713879540346881
https://twitter.com/GERonEconomy/status/1244744086847979527
https://twitter.com/GERonEconomy/status/1040618182757756928


https://twitter.com/UN_Disarmament/status/1334540857119281158


https://twitter.com/EUJapanCentre/status/1197470726393126917


https://twitter.com/architectourGD/status/1340234166139564034


https://twitter.com/4BerlinTokyo/status/1337347549339013122


https://twitter.com/GermanyinJapan/status/1338978391513583617
https://twitter.com/GermanyinJapan/status/1340499666782146561
https://twitter.com/GermanyinJapan/status/1338811182266761216
https://twitter.com/GermanyinJapan/status/1324919755791167489
https://twitter.com/GermanyinWestjp/status/1339369626514419712


https://twitter.com/GermanyinWestjp/status/1340446822419017737
https://twitter.com/GermanyinWestjp/status/1337948350008545282


https://twitter.com/GTAI_de/status/1192455251523198977


https://twitter.com/BotschaftJapan/status/1139095124049367040


https://twitter.com/SHIKIBU_Automat/status/1340837300385632258


https://twitter.com/RickAnderson/status/1340520730010689536


https://twitter.com/EnkiSort33/status/1334625147463086091
https://twitter.com/FutureLuiss/status/1339480456044146691


　https://twitter.com/Forbes/status/1047958289923940354
　https://twitter.com/qingyulaser/status/1341172398087794689
　https://twitter.com/MaxBoot/status/1014526312600522753

World 世界情勢等 Vol.8

All the below links are in English.

取り急ぎ以下（内容事項一部抜粋ご参考まで）貼っておきます。

World Vol.59　cities,history StockMarket,volatility GlobalWealthReport BlackRock WasteManagement NZ Russia VaccineRollout,UK ND,SD,NE,KS,FL

World Vol.58 (U.S., Australia, etc.)　BlackFriday grocers FedEx,DHL,UPS SickLeave Perth Taiwan China salmon TN,KY,NM,WY

World Vol.57 (Joe Biden, Janet Yellen, etc.)　China HumanRights Europe Russia travel FinancialStability Lego,Colosseum MilkyWay Scotland county-by-county OR,AK,HI,NY,MA,MI

World Vol.56 (U.S., etc.)　FederalReserveBanks Pfizer BioNTech Moderna top20counties MI,ME,MA,MT,MO,TX,WV,WY,CO,NE,ND,IA Canada UK(NI)

World Vol.55 (incl 2019)　masks sanctuary Ecuador,chocolate NZ RCEP MD,NM,AZ,VA

World Vol.54 (Eastern Europe, U.S.)　coronavirus GiantShoppingMall EuropeanCapitalOfCulture Montenegro esports OH,TN,UT,NM,ID,CO,IN,KY,TX,FL Quebec,Inuit

World Vol.53 (U.S., etc.)
この日付は11/3となっていますが、少々気を遣うあまり投稿しないまま忘れてしまっており、つい先程投稿しましたので、実質的日付は 12/9 です。
OnlineChess bookstores beaches Walmart bettors election FL,NC,SC,IN,OH

World Vol.52 (U.S.)　food AbsenteeBallot MaskRequirements antitrust,monopoly AmyConeyBarrett AL,AR,TN,TX,NYC

Caucasus Vol.2 (2020 Nagorno-Karabakh War)

なお、先程発見した客観的事実として、弊社英語ウェブサイトの検索欄に「World Vol.」と入れると（そのURLは http://worldsolutions.work/?s=World+Vol. です）、
「 This page isn’t working　　worldsolutions.work is currently unable to handle this request.　HTTP ERROR 500 」
と出て来るようになってしまっています。
最近「World Vol.」シリーズでアメリカ国内の地方テレビ局のツイートを（あくまで一般感覚的に普通に）少々貼っておりましたが、それを検索されるのを好まない人達が居るということかと推察いたします。

Science and Technology 科学技術 Vol.18 ／ #Coronavirus #コロナウイルス Vol.21

All the below links are in English.

取り急ぎ以下（黒字部分は内容事項一部抜粋ご参考まで）貼っておきます。

Science and Technology Vol.49　COVID19 vaccines materials AI,robotics
Science and Technology Vol.48 (incl 2019)　telehealth coronavirus pandemics MachineLearning triage ventilator nurses startup chemicals GPS HorizonEU electrification
Science and Technology Vol.47 (incl 2019)　digitalhealth PhysicalDistancing immunotherapy food molecular metal
Science and Technology Vol.46 (personal protective equipment (PPE) suppliers/manufacturers)　
Science and Technology Vol.45　telemedicine COVID19vaccine ventilators vitaminD kidneyinjury,AKI periosteum
Science and Technology Vol.44　GeorgeRutherford,UCSF MichaelOsterholm,UMN ArtificialIntelligence BreathTestingSystem,Shimadzu,TohokuUniversity
Science and Technology Vol.43　NobelPrizes/Physiology&Medicine/Physics/Chemistry
Science and Technology Vol.42 (miscellaneous)　IgNobelPrizes heart-healthy lutein dexamethasone(Trump)
Science and Technology Vol.41 (miscellaneous)　3Dimaging/3Dprinting underwaterRobot water foodwaste nutrition planet
Science and Technology Vol.40　symptoms LosAngeles colleges,universities BigData,DataScience 3Dprinting,PPE ClimateChange Antarctica BraineatingAmoeba

#Coronavirus #コロナウイルス Vol.20（vaccines ワクチン） ／ U.S.A. アメリカ Vol.130（Massachusetts マサチューセッツ州 Vol.4 / New York ニューヨーク州 Vol.5: pharmaceutical corporations 製薬会社 – Moderna モデルナ社、Pfizer ファイザー社）

All the below links, excerpts, and tweets are in English.

cf. #Coronavirus #コロナウイルス Vol.19（vaccines ワクチン） ／ U.S.A. アメリカ Vol.129（New York ニューヨーク州 Vol.4 / Massachusetts マサチューセッツ州 Vol.3: pharmaceutical corporations 製薬会社 – Pfizer ファイザー社、Moderna モデルナ社）

昨日に引き続き取り急ぎ以下貼っておきます。

Multidose COVID-19 vaccines will test state tracking systems: People have to get two shots of the same type of vaccine (12/04/2020) | @verge
… Both take two doses, given a few weeks apart, and both could be circulating at the same time. And that’s just the two front-runners. Other multidose vaccines are still in the development pipeline.
There are a few ways states, doctors, and patients could keep the dosages straight, says Claire Hannan, executive director of the Association of Immunization Managers. In the simplest solution, everyone who gets a COVID-19 vaccine will also get a card that tells them which vaccine they had and when their next dose should be. But that’s the last line of defense in a complex vaccine tracking system. “As the backup to the backup to the backup, they’ll hand out cards,” Hannan says.
Ideally, the cards won’t be necessary because patients and doctors will be able to rely on electronic records and digital registry systems to keep track of who got which vaccine and when they got it. Through the pandemic, states have struggled with digital systems for other key areas, like COVID-19 testing – sometimes relying on fax machines and incomplete, handwritten forms to send information from testing sites to local health departments. But Hannan says the US immunization data collection systems at the state level are prepared to manage the expected crush of information from an unprecedented mass vaccination campaign like the one the country is about to start. Most tools were in place even before the pandemic hit. …
Big health systems with robust electronic health record management will likely have an easier time with this process than smaller clinics, says Howard Forman, a professor of public health, management, and economics at Yale University. “They’re used to keeping track of whether patients have had their followup appointments…
… Each state has its own Immunization Information System (IIS), a centralized registry that keeps track of every vaccine each person vaccinated in that state has received. Vaccination clinic software and electronic health records systems feed into those registries, which help doctors keep track of the vaccination records for individual patients, and also give each state big-picture data on vaccination rates in individual communities.
A state-level IIS can also notify doctors and patients when people are due for a second dose of a vaccine. They already use them to keep track of doses for the meningitis B vaccine…
The systems in place to track vaccinations today are much more advanced than they were in 2009, when the country struggled to distribute and track the H1N1 flu vaccine (which was only one shot), and electronic health records were rare. Only some states used their IIS programs. Many states had to rely on SurveyMonkey to connect with health care providers about vaccine delivery…

Moderna reaffirms 20M vaccine dose goal for December (12/04/2020) | @BosBizJournal
… The biotech has enlisted Italian firm Lonza to ramp up production to 500 million to one billion doses of the vaccine annually and Catalent Inc. to make all of the labels, seals and glass vials. Local life sciences unicorn Ginkgo Bioworks has also been helping Moderna optimize its production of raw materials for the drug.
Moderna has additionally hired another 150 employees to produce the vaccine out of its Norwood manufacturing facility. …

Moderna says its vaccine candidate has ‘potential’ to confer longer-term immunity (12/03/2020) | @MarketWatch
…National Institute of Allergy and Infectious Diseases…
The company said it remained confident it will have 20 million doses of the vaccine candidate available in the U.S. by the end of the year, and it expects to have between 100 million and 125 million doses available globally in the first quarter of next year.
Of these, between 85 million and 100 million will be available in the U.S. and between 15 million and 25 million will be available elsewhere…

Moderna’s 3-month data raise hopes for COVID-19 vaccine durability (12/04/2020) | @FierceBiotech
… Moderna shared details of the NEJM letter alongside an update on its effort to scale up production. …
Moderna Provides Updates on the Clinical Development and Production of Its COVID-19 Vaccine Candidate (12/03/2020) | @moderna_tx
… “mRNA-1273 produced high levels of binding and neutralizing antibodies that declined slightly over time, as expected, but they remained elevated in all participants three months after the booster vaccination.”…
Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination (12/03/2020) | @NEJM

What it feels like to get Moderna’s COVID-19 vaccine: “It’s not pleasant, but it’s definitely worth the risk of developing these side effects to make sure we can find an end to this pandemic.” (12/03/2020) | @BostonDotCom
Saginaw doctor who took part in Moderna vaccine trial seeks to reassure public (12/04/2020) | @MLive
Moderna Says COVID Vaccine Could Create Immunity For At Least Three Months (w Video; 12/04/2020) | @wbz
New data shows people who got Moderna vaccine still had antibodies 3 months later: The data came from a small number of phase 1 participants. (04/12/2020) | @ABCNews
Continuing COVID-19 vaccine trials may put some volunteers at unnecessary risk. Is that ethical? (w Video; 12/04/2020) | @USATODAY
No legal grounds for employers to force employees to get vaccinated, say experts (12/04/2020) | @CTVNews

Canada doubles Moderna vaccine order, daily COVID-19 cases could top 10,000 by January (12/04/2020) | @reuters
… Anand also said FedEx Corp and Innomar Strategies, a Canada-based division of AmerisourceBergen, had been contracted by the federal government to provide logistical support on vaccine delivery.

Moderna COVID vaccine best for Nunavut because of storage, shipping: top doctor (12/04/2020) | @CKOMNews
… Moderna’s vaccine is preferred because the Pfizer one requires cold storage and shipping would be too difficult in Nunavut. …

Two vaccines might get emergency approval this month. Here’s what you need to know (12/01/2020) | @latimes
What about those second doses?
The CDC’s vaccine tracking system will monitor who gets a first dose and will coordinate with Pfizer and Moderna on the shipment of the second doses. This means medical centers can administer all the doses they initially receive without having to hold onto half for the second shot.
How long before I can drive to my local pharmacy and get a vaccine?
If you’re healthy and a nonessential worker, you will have to wait. Most experts feel that the immunization effort in the United States will be in high gear by late spring and early summer of 2021…

Moderna to submit Covid-19 vaccine to FDA as full results show 94% efficacy (11/30/2020) | @statnews
… Moderna said that safety data is being reviewed continuously, but that there are no new serious safety concerns. The most common adverse events included site pain, fatigue, muscle or bone pain, headaches, and redness at the injection site. The reactions were more serious in the vaccine group after patients received a second dose. The results Pfizer and BioNTech released 12 days ago for their vaccine are roughly similar. …
… Each strand of synthetic mRNA is designed to encode for a protein found on the surface of SARS-CoV-2, the virus that causes Covid-19. Those mRNA strands enter the body’s cells and instruct them to produce that protein. The immune system then recognizes it as a foreign invader and produces antibodies that protect against Covid-19 if a person is later exposed to the virus.
The Covid-19 vaccine would be Moderna’s first product approved by the FDA and, assuming Pfizer’s vaccine is approved first, only the second mRNA medicine ever licensed. …

Moderna’s COVID-19 Vaccine Candidate Gets More Good News (w Voice; 11/30/2020) | @NPR
… Both use the same novel technology. Instead of injecting a weakened or dead virus, which is a common strategy for vaccines, these products are essentially small pieces of genetic material. When that’s injected into a person’s arm, it’s picked up by cells in the immune system. The cells read the genetic code and use that to produce a protein that is actually a key fragment of the coronavirus. The body then builds antibodies that latch onto that fragment, so if and when someone encounters the actual coronavirus, the body is primed to fight it off with antibodies. …

#Coronavirus #コロナウイルス Vol.19（vaccines ワクチン） ／ U.S.A. アメリカ Vol.129（New York ニューヨーク州 Vol.4 / Massachusetts マサチューセッツ州 Vol.3: pharmaceutical corporations 製薬会社 – Pfizer ファイザー社、Moderna モデルナ社）

All the below links, excerpts, and tweets are in English.
cf.
U.S.A. アメリカ Vol.107（New York ニューヨーク州 Vol.2: pharmaceutical corporations 製薬会社）
U.S.A. アメリカ Vol.113（Massachusetts マサチューセッツ州 Vol.2: pharmaceutical corporations 製薬会社）

取り急ぎ以下貼っておきます。

Pfizer And Moderna Face Their Biggest Challenge: Vaccinating The World (12/03/2020) | @IBDinvestors
… The obstacles can’t be overestimated, experts say. The vaccine supply chain is mindbogglingly complex. It involves local, state and federal authorities as well as hospitals, pharmacies and doctors’ offices.
The two most advanced coronavirus vaccines must be stored at specific temperatures and given in two doses several weeks apart. Stakeholders must keep tabs on who gets which vaccine and when. And don’t forget the public perception challenges of vaccinating people with drugs that went through clinical testing at record speeds.
Experts say 60% to 80% of the world must be vaccinated to achieve herd immunity. It will be many months – or years – before that happens as vaccine makers iron out supply constraints. Besides the Covid-19 vaccine companies themselves, a raft of other parties like drug distribution company McKesson (MCK) will be involved.
…the Centers for Disease Control and Prevention. The agency has overseen vaccine distribution in the U.S. for decades, including the national effort to vaccinate during the H1N1 influenza pandemic in 2009.
The coronavirus vaccination effort will probably look similar to that…
First, vaccination sites will need to enroll in the CDC’s Covid-19 vaccine distribution program. These sites will include doctors’ offices, clinics, hospitals and pharmacies. The program ensures these locations have enough well-trained staff, the right equipment and space to vaccinate large numbers of people.
Then, the vaccination sites will request doses of the coronavirus vaccine through a state agency…
Public health officials will then confirm the vaccination site is approved. If so, the order will head to the CDC. …
In August, the CDC tapped McKesson to help it distribute all coronavirus vaccines. …McKesson could rely on UPS, DHL and FedEx trucks to help it get the job done.
Pfizer, on the other hand, has a bigger challenge. The company’s coronavirus vaccine must be stored at ultracold temperatures. How cold? Penguins would find these temperatures chilly. …
Moderna’s vaccine can live in a standard refrigerator for 30 days. It can also be frozen for six months. Once thawed, providers must administer the vaccine within 12 hours – or toss it out. That creates a logistical challenge for transportation.
“Moderna will be heavily reliant on external suppliers…It will be using companies like CryoPort (CYRX), Stirling Ultracold and CH Robinson (CHRW) to work out cold chain logistics plus storage and shipping management.” …
…Pfizer has developed a special shipping container that can store the coronavirus vaccine for 10 days unopened…
The vaccine can be stored in an ultracold freezer for up to six months. It can stay in the shipping container for up to 30 days when replenished with dry ice every five days. Or, the drug can be stored for five days in a standard refrigerator.
…the strict storage requirements limit where Pfizer’s vaccine can be used. Those ultracold freezers cost about $20,000 apiece. …
…”Imagine getting one dose to Appalachia, a rural community. Now imagine having to come back and making sure everyone who got the first dose also gets the second one. That’s a challenge.”
…it’s likely the Pfizer vaccine will go to more populous locations with cold-storage capabilities. Coronavirus vaccine stock Moderna will probably send its drug to more rural communities.
…expects Pfizer to generate $875 million in coronavirus vaccine sales in 2020 and $7.25 billion in 2021. Eventually, that will trend down to $700 million to $800 million each year, depending on how often people need booster shots of the vaccine. …
“The drugmaker that gets this thing out first…Overnight, Pfizer becomes one of the most loved brands in America. It’s the McDonald’s (MCD) of the pharma industry.”
COVID19 vaccine-efforts

Pfizer to Ship Half as Many Coronavirus Vaccine Doses as Originally Planned in Initial Phase (12/03/2020) | @themotleyfool
…”Scaling up the raw material supply chain took longer than expected, and it’s important to highlight that the outcome of the clinical trial was somewhat later than the initial projection.”
BNT162b2, which showed an extremely high efficacy rate of 95% with no serious safety concerns in phase 3 clinical trials, has been submitted for similar approvals throughout the European Union, and with the U.S. Food and Drug Administration (FDA). In the wake of the U.K. approval, Pfizer and BioNTech anticipate decisions from other major regulators this month. …

Pfizer Scaled Back Vaccine Output Targets Earlier This Year (12/03/2020) | @business
…supply-chain problems caused the New York-based drugmaker to reduce the number of vaccines…led Pfizer shares to fall as much as 3.1% and caused the wider stock market to dip. The S&P 500 ended Thursday’s trading down 0.1%. …
Moderna Inc., which has also submitted a messenger RNA-based vaccine to the FDA for emergency clearance, said in a statement on Thursday it would have between 100 million and 125 million doses available globally in the first quarter of 2021. …

UK becomes the first to approve Pfizer-BioNTech Covid vaccine, rollout due next week (12/02/2020) | @CNBC
…with elderly people in care homes and medical workers first in line. …
“The government has today accepted the recommendation from the independent Medicines and Healthcare products Regulatory Agency (MHRA)…
Pfizer and BioNTech announced in July an agreement with the U.K. to supply 30 million doses of its mRNA-based vaccine…increased to 40 million doses in early October. As a two-dose vaccine, the U.K. will have enough doses to vaccinate around a third of its 66 million population. …
“I consider this decision to be problematic and recommend that EU Member States do not repeat the process in the same way. A few weeks of thorough examination by the European Medicines Agency is better than a hasty emergency marketing authorization of a vaccine,” said Peter Liese, a member of German Chancellor Angela Merkel’s party…

Pfizer supply chain challenges led to slashing COVID-19 vaccine production target – WSJ (12/03/2020) | @reuters,@YahooFinance
…anticipates producing 50 million doses of its COVID-19 vaccine this year. That is down from an earlier target of 100 million doses. Pfizer’s vaccine relies on a two dose regimen, meaning 50 million doses is enough to inoculate 25 million people. …
David Perdue bought Pfizer stock – a week before company said it would develop a vaccine (12/03/2020) | @salon

Australia オーストラリア Vol.11（Prime Minister Morrison’s visit to Japan and bilateral summit meeting モリソン豪首相訪日・日豪首脳会談）


https://twitter.com/ASPI_org/status/1329289583347920896


https://twitter.com/BryceWakefield/status/1329031603214028801


https://twitter.com/ANZCCJ/status/1328551302368874496


https://twitter.com/livcaisley/status/1328859036549214209
https://twitter.com/livcaisley/status/1328603074391314432
https://twitter.com/livcaisley/status/1328990738349051904


https://twitter.com/livcaisley/status/1328619240497180674

Science and Technology 科学技術 Vol.14 ／ #Coronavirus #コロナウイルス Vol.15（pharmaceutical products 医薬品 Vol.6：drugs 治療薬）

All the below links and excerpts are in English.

Tocilizumab/Atlizumab（Actemra®）に係るリンクと当方作成の抜粋を取り急ぎ以下のとおり貼っておきます。

Effect of Tocilizumab vs Usual Care in Adults Hospitalized With COVID-19 and Moderate or Severe Pneumonia: A Randomized Clinical Trial (w PDF; 10/20/2020) | @JAMANetwork
PDF　
Tocilizumab1 JAMA1-1_keyTocilizumab2 JAMA1-2_effectTocilizumab3 JAMA1-3_effect

Efficacy and safety of tocilizumab in COVID-19 patients: A living systematic review and meta-analysis (w PDF; 11/05/2020) | @CMIJournal
Conclusion
Cumulative moderate certainty evidence shows that tocilizumab reduces the risk of mechanical ventilation in hospitalized COVID-19 patients. While RCTs showed that tocilizumab did not reduce short-term mortality, low certainty evidence from cohort studies suggests an association between tocilizumab and lower mortality. We did not observe a higher risk of infections or adverse events with tocilizumab use. This review will continuously evaluate the role of tocilizumab in COVID-19 treatment.

Efficacy of Tocilizumab on Patients With COVID-19 (08/24/2020) | @MGHMedicine,@genentech ClinicalTrials.gov @nlm_news
Brief Summary:
This is a randomized, double blind, multi-center study to evaluate the effects of tocilizumab compared to placebo on patient outcomes in participants with confirmed SARS-CoV-2 infection and evidence of systemic inflammation.
The aim of this study is to test the effect of Tocilizumab on multi-organ dysfunction in a phase 3 randomized controlled trial among hospitalized patients with COVID-19 infection.
Specifically, as compared to placebo, we will test whether tocilizumab is associated with a reduction in multi-organ dysfunction among hospitalized COVID-19 adult patients with elevated inflammatory measures. Multi-organ dysfunction will be measured as the incidence of the following composite endpoint (mechanical ventilation, renal replacement therapy, mechanical support, need for inotropes or vasopressors, liver dysfunction (increased bilirubin), and all-cause mortality). We will also assess multiple pre-specified secondary (exploratory) endpoints and safety endpoints.
We hypothesize that, as compared to placebo, tocilizumab will reduce transfer to the ICU, need for mechanical ventilation, increase rates of hospital discharge in patients diagnosed with severe COVID-19 infection and evidence of exaggerated inflammatory response.

New results from a once-promising therapy show the difficulty of treating covid-19: In one study, the drug, tocilizumab, reduced risk of death in ICU patients, but two others found negligible results with slightly different patients (10/21/2020) | @washingtonpost
Studies offer little hope for tocilizumab in treating COVID (10/20/2020) | @CIDRAP
Time to Reassess Tocilizumab’s Role in COVID-19 Pneumonia (10/20/2020) | @JAMANetwork
Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 (10/20/2020) | @JAMANetwork

Efficacy of Tocilizumab in Patients Hospitalized with Covid-19 (10/21/2020) | @NEJM
Tocilizumab for COVID-19? Three Studies Yield Mixed Findings (10/20/2020) | @JWatch
Tocilizumab for patients with COVID-19 pneumonia. The single-arm TOCIVID-19 prospective trial (w PDF; 21/10/2020) | Journal of Translational Medicine
Appropriate use of tocilizumab in COVID-19 infection (w PDF; 10/2020) | International Journal of Infectious Diseases @ElsevierConnect
PDF　
Tocilizumab4 IJID_Turkey

Roche’s Actemra helps keep coronavirus patients off ventilators despite earlier trial flop (09/18/2020) | @FiercePharma
…Roche is also pairing Actemra with Gilead Sciences’ antiviral Veklury, better known as remdesivir, in the phase 3 Remdacta trial. Eli Lilly’s JAK arthritis med Olumiant combined with Veklury helped patients recover faster in a recent trial run by the National Institute of Allergy and Infectious Diseases.

Tocilizumab/IL-6 Inhibitors | @RealTimeCOVID19
Case report: use of lenzilumab and tocilizumab for the treatment of coronavirus disease 2019. | @WHO
Decreased Mortality in Coronavirus Disease 2019 Patients Treated With Tocilizumab: A Rapid Systematic Review and Meta-analysis of Observational Studies (w PDF; 23/09/2020) | @OUPAcademic
Tocilizumab for treatment patients with COVID-19: Recommended medication for novel disease (09/16/2020) | @NCBI
Efficacy of tocilizumab in COVID‐19: A systematic review and meta‐analysis (w PDF; 12/09/2020) | @WileyGlobal
Glucocorticoids, tocilizumab may reduce complications in COVID-19-related cytokine storm (09/03/2020) | @HealioRheum
Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study (w PDF; 08/14/2020) | @TheLancetRheum
Tocilizumab in patients with severe COVID-19: a retrospective cohort study (w PDF; 08/01/2020) | @TheLancetRheum
Chugai Starts Phase III Clinical Trial of Actemra for COVID-19 Pneumonia in Japan (04/08/2020) | @chugai_cc
What is the role of the IL-6 inhibitor tocilizumab (Actemra) in the treatment of coronavirus disease 2019 (COVID-19)? (11/10/2020) | @Medscape

Australia オーストラリア Vol.10（pharmaceutical corporations 製薬会社）

All the below links and tweets are in English.

取り急ぎ以下貼っておきます。

CSL（豪）の子会社
Pennsylvania Vol.11 (corporations: CSL Behring) / Australia Vol.29
UK Vol.173 (pharmaceutical corporations: Seqirus) / Australia Vol.30

上記リンク内に無い本日までのツイート


https://twitter.com/SamDForever1/status/1325970911258836992


https://twitter.com/DayofImmunology/status/1325371202831962112


https://twitter.com/CSLBehring/status/1322931444545703938


https://twitter.com/thalassaemiaTIF/status/1325715357408120835

ツイッター検索で 上記製薬会社名 及び Japan や 日本の5製薬会社各社名 を入れて出て来たもの

U.S.A. アメリカ Vol.127（US Presidential Election 2020 米国大統領選挙）

All the below links are in English.

取り急ぎ以下貼っておきます。

US Presidential Election 2020 Vol.9　cspan、NewsHour、TIME、Newsweek、HuffPost、voxdotcom
US Presidential Election 2020 Vol.8　NPR、politico、thehill、drudgereportfeed、BreitbartNews、DailyCaller
US Presidential Election 2020 Vol.7　CBSNews、NBCNews、CNN、ABC、FoxNews、nytimes、washingtonpost
2020PresidentialResults_AP

cf.
9/1　US Presidential Election 2020 Vol.6 (The Hill)
9/1　US Presidential Election 2020 Vol.5 (Politico)
9/1　US Presidential Election 2020 Vol.4 (Politico)
8/31　US Presidential Election 2020 Vol.3 (American Enterprise Institute, Heritage Foundation)
8/31　US Presidential Election 2020 Vol.2 (Brookings Institution)
8/29　US Presidential Election 2020 Vol.1 (conventions)
10/29　U.S.A. Vol.126（Joe Biden For President）
10/29　U.S.A. Vol.125（Donald J. Trump for President）

U.S.A. Vol.126（Joe Biden For President）

The below excerpts are on our own.

BUILD BACK BETTER: JOE BIDEN’S JOBS AND ECONOMIC RECOVERY PLAN FOR WORKING FAMILIES
… In this time of crisis, Joe Biden has a plan to create millions of good-paying jobs and to give America’s working families the tools, choices, and freedom they need to build back better.
That starts with a real strategy to deal with the pandemic. We can’t solve the jobs crisis until we solve the public health crisis. …
Biden will also provide further immediate relief to working families, small businesses, and communities. Biden will:
– Provide state, local, and tribal governments with the aid they need so educators, firefighters and other essential workers aren’t being laid off.
– Extend COVID crisis unemployment insurance to help those who are out of work.
– Provide a comeback package for Main Street businesses and entrepreneurs.
And, Biden will immediately put people to work by enlisting them to help fight the pandemic, including through a Public Health Jobs Corps.
… The Biden plan will mobilize the American people in service of four bold, national efforts to address four great national challenges. As President, Biden will:
– Mobilize American manufacturing and innovation to ensure that the future is made in America, and in all of America. …
– Mobilize American ingenuity to build a modern infrastructure and an equitable, clean energy future. …
– Mobilize American talent and heart to build a 21st century caregiving and education workforce which will help ease the burden of care for working parents, especially women. …
– Mobilize across the board to advance racial equity in America. …
Building back better means an updated social contract that treats American workers and working families as essential at all times, not just times of crisis…a decent wage, at least $15 per hour…universal paid sick days and 12 weeks of paid family and medical leave…
Building back better means helping small businesses and entrepreneurs come out the other side of this crisis strong, while demanding more from corporate America. …
…reversing some of Trump’s tax cuts for corporations and imposing common-sense tax reforms that finally make sure the wealthiest Americans pay their fair share.

A TALE OF TWO TAX POLICIES: TRUMP REWARDS WEALTH, BIDEN REWARDS WORK
I. Trump’s Tax Proposal In An Economic Crisis: A New Billionaire Tax Cut
… In Trump’s America, a working family making $65,000 will pay 22% on every extra dollar they earn, not including payroll taxes, while billionaires will pay just 15% on their profits from investments. …
II. Trump’s Tax Record: Billions For Foreign Investors And Large Multinational Corporations
… In 2018, in the wake of the Trump tax giveaway, 91 companies in the Fortune 500 paid no federal taxes on their income and another 56 paid less than 5 percent. …
Just a few examples of the harmful impact of Trump’s corporate tax giveaway include:
– Wells Fargo saved nearly $6.5 billion from the tax giveaway in 2018 and 2019, then authorized $40 billion worth of stock buybacks, raised interest rates on borrowers, and announced that it would lay off up to 26,000 workers.
– The pharmaceutical giant AbbVie received a $1.3 billion tax handout, announced $10 billion worth of buybacks, then increased prices for more than 10 of its products, including the arthritis medication, Humira.
– JPMorgan Chase pocketed $8.76 billion in tax breaks in 2018 and 2019 and yet last year still charged consumers $2 billion in overdraft fees, and cut hundreds of jobs.
– Harley-Davidson announced it would repurchase almost $700 million worth of its own stock, slash 350 manufacturing jobs, and shift some of its production overseas.
– AT&T cut thousands of jobs, while Trump gave them $1 billion in federal contracts and a $3 billion per year tax cut.
– Boeing offshored more than 2,000 U.S. jobs and announced billions in stock buybacks while receiving $29 billion in contracts and a $1.1 billion tax cut from Trump.
III. Biden’s Plan: Make The Wealthy And Corporations Pay Their Fair Share, And Provide Tax Relief For Working Families
… Joe Biden will not raise taxes on anyone making less than $400,000. Period. But he will ask wealthy Americans and big corporations to pay their fair share, including by:
– Raising the corporate tax rate to 28 percent.
– Requiring a true minimum tax on ALL foreign earnings of United States companies located overseas so that we do our part to put an end to the global race to the bottom that rewards global tax havens. This will be 21% — TWICE the rate of the Trump offshoring tax rate and will apply to all income.
– Imposing a tax penalty on corporations that ship jobs overseas in order to sell products back to America.
– Imposing a 15% minimum tax on book income so that no corporation gets away with paying no taxes.
– Raising the top individual income rate back to 39.6 percent.
– Asking those making more than $1 million to pay the same rate on investment income that they do on their wages.
…

THE BIDEN PLAN TO BUILD A MODERN, SUSTAINABLE INFRASTRUCTURE AND AN EQUITABLE CLEAN ENERGY FUTURE
… Amidst the COVID-19 pandemic, he ignored public health experts, praised the Chinese government, and failed to take the actions needed to protect the American people. …
Just as with COVID-19, Donald Trump has denied science and failed to step up in the face of the climate crisis. He has called it a hoax. He has allowed our infrastructure to deteriorate and farmers’ fields to flood. He has held back American workers from leading the world on clean energy, giving China and other countries a free pass to outcompete us in key technologies and the jobs that come with them. …
… He will launch a national effort aimed at creating the jobs we need to build a modern, sustainable infrastructure now and deliver an equitable clean energy future.
… Biden will make a $2 trillion accelerated investment…
– Infrastructure:…from roads and bridges to green spaces and water systems to electricity grids and universal broadband…
– Auto Industry: Create 1 million new jobs…
– Transit: Provide every American city with 100,000 or more residents with high-quality, zero-emissions public transportation options through flexible federal investments with strong labor protections…
– Power Sector:…a carbon pollution-free power sector by 2035. …
– Buildings: Upgrade 4 million buildings and weatherize 2 million homes over 4 years, creating at least 1 million good-paying jobs with a choice to join a union…
– Housing: Spur the construction of 1.5 million sustainable homes and housing units.
– Innovation: Drive dramatic cost reductions in critical clean energy technologies, including battery storage, negative emissions technologies, the next generation of building materials, renewable hydrogen, and advanced nuclear…
– Agriculture and Conservation: Create jobs in climate-smart agriculture, resilience, and conservation, including 250,000 jobs plugging abandoned oil and natural gas wells and reclaiming abandoned coal, hardrock, and uranium mines…
– Environmental Justice…
Biden also reaffirms his commitment to fulfill our obligation to the workers and communities who powered our industrial revolution and decades of economic growth, as outlined in his original climate plan. …
– BUILD A MODERN INFRASTRUCTURE …
– POSITION THE AMERICAN AUTO INDUSTRY TO WIN THE 21ST CENTURY …
– CREATE MILLIONS OF JOBS PRODUCING CLEAN ELECTRIC POWER FOR AMERICAN FAMILIES AND BUSINESSES …
– UPGRADE THE BUILDING SECTOR: RETROFITTING BUILDINGS, UPGRADING SCHOOLS, AND BUILDING HOMES ACROSS AMERICA …
– PURSUE A HISTORIC INVESTMENT IN CLEAN ENERGY INNOVATION … A major focus of Biden’s commitment to increase federal procurement by $400 billion in his first term…
– INVEST IN SUSTAINABLE AGRICULTURE AND CONSERVATION …
– SECURE ENVIRONMENTAL JUSTICE AND CREATE EQUITABLE ECONOMIC OPPORTUNITY …

LIFT EVERY VOICE: THE BIDEN PLAN FOR BLACK AMERICA
THE BIDEN AGENDA FOR THE LATINO COMMUNITY

BIDEN-SANDERS UNITY TASK FORCE RECOMMENDATIONS (PDF)