Science and Technology 科学技術 Vol.11 / #Coronavirus #コロナウイルス Vol.13(pharmaceutical products 医薬品 Vol.4:drugs 治療薬)

All the below links and excerpts are in English.


COVID-19 (coronavirus) drugs: Are there any that work? | @MayoClinic
Antiviral drugs. In addition to remdesivir, other antiviral drugs being tested include favipiravir and merimepodib. …
Dexamethasone. …reduces the risk for deaths by about 30% for people on ventilators and by about 20% for people who needed supplemental oxygen. … Other corticosteroids, such as prednisone, methylprednisolone or hydrocortisone, may be used if dexamethasone isn’t available. However, their effectiveness isn’t yet known. …
Anti-inflammatory therapy.
Immune-based therapy. … Convalescent plasma is blood donated by people who’ve recovered from COVID-19. …mesenchymal stem cells and monoclonal antibodies.
・… Researchers study amlodipine and losartan. But it’s not yet…
Hydroxychloroquine and chloroquine. These malaria drugs… the FDA withdrew that authorization…
Drugs to prevent COVID-19.

The Latest Research on COVID-19 Treatments and Medications in the Pipeline (10/23/2020) | @GoodRx
Commonly used treatments for COVID-19 and therapies with emergency use authorizations (EUAs)
Remdesivir (Veklury)
Convalescent plasma
New treatments in early phase studies
Monoclonal antibodies (MABs) … Regeneron and Eli Lilly are two companies that both have MABs in development for COVID-19, currently called REGN-COV2 and LY-CoV555, respectively. …
Treatments that the NIH recommend against using for COVID-19
Hydroxychloroquine and chloroquine
Azithromycin … One research group looked at azithromycin in combination with hydroxychloroquine for COVID-19. They reported that 93% of patients cleared the virus after 8 days, but there was no control group so we don’t know if people would have cleared the virus on their own without the medications. There are concerns about potentially serious side effects when using azithromycin and hydroxychloroquine together. The NIH currently recommends against using azithromycin for COVID-19.
Tocilizumab (Actemra) and other IL-6 inhibitors … By blocking IL-6, tocilizumab helps to calm down the immune system and is believed to also help with managing cytokine storms.
Research on tocilizumab started with a study from France, which reported that people who got tocilizumab were less likely to require ventilation or die. Another study from Italy found that those who got tocilizumab had a lower death rate, though about the same percentage of patients from both groups needed ventilators. On the other hand, tocilizumab did not help COVID-19 patients with early-stage pneumonia. A phase 3 study from the manufacturer also found that tocilizumab did not help for hospitalized COVID-19 patients with severe pneumonia. …
… They showed that patients with severe symptoms who got Kevzara did worse compared to placebo, but patients who had even more severe (critical) symptoms improved compared to placebo. …
Kinase inhibitors … acalabrutinib (Calquence); baricitinib (Olumiant); ruxolitinib (Jakafi); tofacitinib (Xeljanz) …
Kaletra (lopinavir/ritonavir)
Repurposed medications with minimal COVID-19 data
Tamiflu (oseltamivir)
Avigan (favipiravir) and other antiviral medications … In vitro studies have shown that high doses of favipiravir were able to prevent human cells from being infected with SARS-CoV-2. …
Colcrys (colchicine)

Coronavirus Drug and Treatment Tracker (10/29/2020) | @nytimes
Blocking the Virus – Antivirals can stop viruses such as H.I.V. and hepatitis C from hijacking our cells. …
Recombinant ACE-2
Lopinavir and ritonavir
Hydroxychloroquine and chloroquine
Mimicking the Immune System -… Drugs might help people who can’t mount an adequate defense.
Convalescent plasma
Monoclonal antibodies
Putting Out Friendly Fire – The most severe symptoms of Covid-19 are the result of the immune system’s overreaction to the virus. …
Dexamethasone and Other Corticosteroids
Cytokine Inhibitors
Blood filtration systems
Stem cells
Other Treatments
Pseudoscience and Fraud

Treatments for COVID-19: What helps, what doesn’t, and what’s in the pipeline (10/23/2020) | @HarvardHealth

投稿者: ワールド ソルーションズ