Science and Technology 科学技術 Vol.10 / #Coronavirus #コロナウイルス Vol.12(pharmaceutical products 医薬品 Vol.3:vaccines ワクチン)

All the below links and excerpts are in English.

(The below Vaccine Tracker is from @nytimes.)

Coronavirus Vaccine Tracker (10/24/2020) | @nytimes
〇 Genetic Vaccines – Vaccines that deliver…coronavirus’s own genes into our cells to provoke an immune response.
• Moderna & National Institutes of Health [PHASE 3] mRNA
…planned to wait until a significant number of volunteers became sick with Covid-19 and then see how many had been vaccinated. It may take till the end of 2020 or early 2021 to reach the necessary numbers.
• BioNTech & Pfizer & Fosun Pharma (China) [PHASE 2 & 3] mRNA
… Pfizer and BioNTech would not apply for an emergency use authorization before late November at the earliest. …
…will have to be chilled to minus 80 degrees Celsius (minus 112 degrees Fahrenheit) until it’s ready to be injected.
• Zydus Cadila (India) [PHASE 2] DNA-based
• CureVac (Germany) [PHASE 2] mRNA
• Imperial College London (UK) & Morningside Ventures (UK) [PHASE 1 & 2] “self-amplifying” RNA
• AnGes (Japan) & Osaka University (Japan) & Takara Bio (Japan) [PHASE 1 & 2] DNA-based
• Arcturus Therapeutics (CA) & Duke-NUS Medical School (Singapore) [PHASE 1 & 2] mRNA
• Inovio (PA) [PHASE 1] DNA-based
• Genexine (South Korea) [PHASE 1] DNA-based
• Academy of Military Medical Sciences (China) & Suzhou Abogen Biosciences (China) & Walvax Biotechnology (China) [PHASE 1] mRNA-based
• Chulalongkorn University (Thailand) & Chula Vaccine Research Center (Thailand) [PHASE 1] mRNA-based
• Entos Pharmaceuticals (Canada) [PHASE 1] DNA
• Sanofi (France) & Translate Bio (MA) [PRECLINICAL] mRNA

〇 Viral Vector Vaccines – Vaccines that contain viruses engineered to carry coronavirus genes. …
• CanSino Biologics (China) & Academy of Military Medical Sciences (China) [PHASE 3]
• Gamaleya Research Institute (Russia) [PHASE 3]
• Johnson&Johnson & Beth Israel Deaconess Medical Center (MA) [PHASE 3]
• AstraZeneca & University of Oxford [PHASE 2 & 3]
ReiThera (Italy) & Lazzaro Spallanzani National Institute for Infectious Diseases (Italy);Vaxart (CA);Merck & Themis Bioscience (Austria) & Institut Pasteur (France);German Center for Infection Research (Germany);Merck & IAVI (NY);ImmunityBio (CA);Novartis …
〇 Protein-Based Vaccines – Vaccines that contain coronavirus proteins but no genetic material. …
• Novavax [PHASE 3]
• Anhui Zhifei Longcom (China) & Chinese Academy of Medical Sciences (China) [PHASE 2]
Finlay Vaccine Institute (Cuba);Vector Institute (Russia);Sanofi & GSK、SpyBiotech (UK);Clover Biopharmaceuticals (China) & GSK & Dynavax (CA); University of Queensland (Australia) & CSL (Australia);Medicago (Canada) & GSK & Dynavax;Vaxine (Australia);Kentucky BioProcessing (KY);Medigen (Taiwan) & Dynavax;Adimmune (Taiwan);COVAXX (NY) …
〇 Inactivated or Attenuated Coronavirus Vaccines – Vaccines created from weakened coronaviruses…
• Wuhan Institute of Biological Products (China) [PHASE 3]
• Sinopharm (China) [PHASE 3]
• Sinovac Biotech (China) [PHASE 3]
• Indian Council of Medical Research (India) & National Institute of Virology (India) & Bharat Biotech (India) [PHASE 3]

Johnson & Johnson, AstraZeneca coronavirus vaccine trials set to resume: Investigators found the unexplained illnesses in both trials appeared unconnected to the vaccines (10/24/2020) | @washingtonpost
… In the Johnson & Johnson trial, which was paused on Oct. 12, a man who received a vaccination suffered a stroke that may have been triggered by an infection. To conclude it was not likely to be related to the shot, investigators probed not only the medical details of the event, but also examined a safety database of 100,000 people who have received vaccines that use the same underlying technology. …
… The company is testing the only vaccine that aims to protect people with a single shot; other prospective vaccines require a return visit and second shot three to four weeks after the first to trigger a protective immune response.
It was the second late-stage vaccine trial put on hold in recent weeks; the vaccine being developed by AstraZeneca and the University of Oxford was halted on Sept. 6 after a British participant developed a neurological problem. …
… Carlos del Rio, an infectious diseases physician at Emory University School of Medicine. “As long as the data and safety monitoring board has reviewed the data and says its OK to proceed, we proceed.”
… William Hartman, a principal investigator of the AstraZeneca trial at the University of Wisconsin Hospital and Clinics. “It is too soon to tell whether participant enthusiasm will approach what it was prior to the pause. …

Covid: More coronavirus vaccine trials in Wales ‘within weeks’ (24/10/2020) | @BBC

Rush for results could lead to inferior Covid vaccine, say scientists (25/10/2020) | @guardian

Dozens of COVID-19 vaccines are in development. Here are the ones to follow. : Here are the COVID-19 vaccine prospects that have made it to phase three trials and beyond. (10/13/2020) | @NatGeo
• Novavax (MD) NVX-CoV2373
• Johnson & Johnson (NJ) JNJ-78436735
• Moderna Therapeutics (MA) mRNA-1273
• Pfizer (NY) & BioNTech (Germany) BNT162b2
• University of Oxford (UK) & AstraZeneca (UK) ChAdOx1 nCoV-19
• Sinovac (China) & Butantan (Brazil) CoronaVac
• Sinopharm (China) & Wuhan Institute of Biological Products (China) None
• Murdoch Children’s Research Institute (Australia) & University of Melbourne (Australia) Bacillus Calmette-Guerin BRACE trial
• CanSino Biologics (China) Ad5-nCoV
• The Gamaleya National Center of Epidemiology and Microbiology (Russia) Sputnik V

投稿者: ワールド ソルーションズ